Evidence map›Paper›PMID 29932035›Full record

ReviewCurrent protein & peptide science2019

Emerging Antitumor Activities of the Bitter Melon (Momordica charantia).

Evandro Fei Fang, Lynn Froetscher, Morten Scheibye-Knudsen, Vilhelm A Bohr, Jack Ho Wong, Tzi Bun Ng

Abstract readReview
In one paragraph

Review in Current protein & peptide science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The metabolic effect ofFrontiers in nutrition · 2023
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Diverse roles of bitter melon (Journal of cancer metastasis and treatment · 2021
    Article
  9. Bitter Melon (Cancers · 2020
    Review
  10. Cucurbitane-Type Triterpenoids from the Vines ofJournal of natural products · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Evandro Fei FangLaboratory of Molecular Gerontology, National Institute on Aging, NIH, United States.
Lynn FroetscherLaboratory of Molecular Gerontology, National Institute on Aging, NIH, United States.
Morten Scheibye-KnudsenLaboratory of Molecular Gerontology, National Institute on Aging, NIH, United States.
Vilhelm A BohrLaboratory of Molecular Gerontology, National Institute on Aging, NIH, United States.
Jack Ho WongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Tzi Bun NgSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.

Funding

Oxidative DNA Damage And Its ProcessingZIAAG000727 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2022
$8.4M
Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

Bitter melon or bitter gourd (Momordica charantia) is a common vegetable in Asia and it is distinctive for its bitter taste. As an ingredient in folk medicine, research from different laboratories in recent years supports its potential medicinal applications with anti-tumor, anti-diabetic, anti-HIV activities in both in vitro and animal studies. In this short review, we summarize herein the recent progress in the antitumor aspect of bitter melon with a focus on the underlying molecular mechanisms. Further mechanistic studies as well as clinical trials are necessary to further verify its medicinal applications.

Indexed as

Antineoplastic AgentsPlants, MedicinalAnimalsHumansMomordica charantiaNeoplasmsPhytotherapyAntineoplastic Agentsanticancerapoptosisbitter melonDNA damagemedicinal applications.Momordica charantia

Identifiers

PMID29932035
PMCPMC6486373

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.