ArticleBrain and behavior2018
The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Factors associated with brain ageing - a systematic review.BMC neurology · 2021Pooled it
- Aging beyond diagnosis: the MRI brain age gap across disorders.GeroScience · 2026Review
- MDFNet: a multi-dimensional feature fusion model based on structural magnetic resonance imaging representations for brain age estimation.Magma (New York, N.Y.) · 2026Article
- Regional brain aging patterns reveal disease-specific pathways of neurodegeneration.medRxiv : the preprint server for health sciences · 2025Article
- Brain volumes discriminate clinical dementia rating scale categories.Scientific reports · 2025Article
- Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.Molecular psychiatry · 2025Article
- BrainAge moderates associations between Alzheimer's disease biomarkers and cognitive decline: a meta-analysis across A4/LEARN, HABS and ADNI cohorts.medRxiv : the preprint server for health sciences · 2025Article
- Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment.Scientific reports · 2025Article
- AI-powered integration of multimodal imaging in precision medicine for neuropsychiatric disorders.Cell reports. Medicine · 2025Review
- Neuropsychiatric symptoms and neuroimaging-based brain age in mild cognitive impairment and early dementia: A multicenter study.Psychiatry and clinical neurosciences · 2025Article
- Neurofind: using deep learning to make individualised inferences in brain-based disorders.Translational psychiatry · 2025Article
- [European journal of nuclear medicine and molecular imaging · 2024Article
- Dynamic undirected graphical models for time-varying clinical symptom and neuroimaging networks.Statistics in medicine · 2024Article
- Brain age as a biomarker for pathological versus healthy ageing - a REMEMBER study.Alzheimer's research & therapy · 2024Article
- Brain age gap estimation using attention-based ResNet method for Alzheimer's disease detection.Brain informatics · 2024Article
- Brain Age Prediction Using Multi-Hop Graph Attention Combined with Convolutional Neural Network.Bioengineering (Basel, Switzerland) · 2024Article
- Frontal deficits and atrophy in a patient with familial encephalopathy with neuroserpin inclusion bodies detected by single-case voxel-based morphometry: a case report.BMC neurology · 2024Article
- MRI-informed machine learning-driven brain age models for classifying mild cognitive impairment converters.Journal of central nervous system disease · 2024Article
- A deep neural network estimation of brain age is sensitive to cognitive impairment and decline.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe present the Brain-Age Score (BAS) as a magnetic resonance imaging (MRI)-based index for Alzheimer's disease (AD). We developed a fully automated framework for estimating the BAS in healthy controls (HCs) and individuals with mild cognitive impairment (MCI) or AD, using MRI scans.
methodsWe trained the proposed framework using 385 HCs from the IXI and OASIS datasets and evaluated 146 HCs, 102 stable-MCI (sMCI), 112 progressive-MCI (pMCI), and 147 AD patients from the J-ADNI dataset. We used a correlation test to determine the association between the BAS and four traditional screening tools of AD: the Mini-Mental State Examination (MMSE), Clinical Dementia Ratio (CDR), Alzheimer's Disease Assessment Score (ADAS), and Functional Assessment Questionnaire (FAQ). Furthermore, we assessed the association between BAS and anatomical MRI measurements: the normalized gray matter (nGM), normalized white matter (nWM), normalized cerebrospinal fluid (nCSF), mean cortical thickness as well as hippocampus volume.
resultsThe correlation results demonstrated that the BAS is in line with traditional screening tools of AD (i.e., the MMSE, CDR, ADAS, and FAQ scores) as well as anatomical MRI measurements (i.e., nGM, nCSF, mean cortical thickness, and hippocampus volume). DISCUSSION: The BAS may be useful for diagnosing the brain atrophy level and can be a reliable automated index for clinical applications and neuropsychological screening tools.
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