ArticleJournal of biophotonics2018
Quantitative assessment of cell contractility using polarized light microscopy.
Article in Journal of biophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Actomyosin contractility is a potent suppressor of mesoderm induction by human pluripotent stem cells.The Journal of cell biology · 2026Article
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- To label or not: the need for validation in label-free imaging.Journal of biomedical optics · 2024Review
- Collagen density regulates tip-stalk cell rearrangement during angiogenesis via cellular bioenergetics.APL bioengineering · 2024Article
- Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA.Cell reports · 2023Article
- Pre-glycation impairs gelation of high concentration collagen solutions.Journal of biomedical materials research. Part A · 2022Article
- AGE-breaker ALT711 reverses glycation-mediated cancer cell migration.Soft matter · 2022Article
- Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition.Cancers · 2022Article
- The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?Cancers · 2022Review
- Matrix-driven changes in metabolism support cytoskeletal activity to promote cell migration.Biophysical journal · 2021Article
- Dependence of phase transition uniformity on crystal sizes characterized using birefringence.Structural dynamics (Melville, N.Y.) · 2021Article
- Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility.Journal of cell science · 2020Article
- Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth.Cancers · 2019Article
- Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology.Micromachines · 2019Review
- Microscale Interrogation of 3D Tissue Mechanics.Frontiers in bioengineering and biotechnology · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cell contractility regulates multiple cell behaviors which contribute to both normal and pathological processes. However, measuring cell contractility remains a technical challenge in complex biological samples. The current state of the art technologies employed to measure cell contractility have inherent limitations that greatly limit the experimental conditions under which they can be used. Here, we use quantitative polarization microscopy to extract information about cell contractility. We show that the optical retardance signal measured from the cell body is proportional to cell contractility in 2-dimensional and 3-dimensional platforms, and as such can be used as a straightforward, tractable methodology to assess cell contractility in a variety of systems. This label-free optical method provides a novel and flexible way to assess cellular forces of single cells and monolayers in several cell types, fixed or live, in addition to cells present in situ in mouse tumor tissue samples. This easily implementable and experimentally versatile method will significantly contribute to the cell mechanics field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.