Evidence map›Paper›PMID 29931624›Full record

ArticleInternational journal of hematology2018

A unique clinical presentation of de novo acute promyelocytic leukemia as a myeloid sarcoma of the breast.

Iveta Oravcova, Eva Mikuskova, Michaela Leitnerova, Jan Gyarfas, Andrea Mlcakova, Peter Szepe, Lukas Plank, Ludmila Demitrovicova, Vanda Mikudova, Silvia Cingelova and 2 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Myeloid sarcoma of the tongue as a first manifestation of acute promyelocytic leukemia: A case report.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Iveta OravcovaDepartment of Oncohematology II, National Cancer Institute, Klenová 1, 83310, Bratislava, Slovakia. iveta.oravcova@nou.sk.ORCID http://orcid.org/0000-0003-4586-6046
Eva MikuskovaDepartment of Oncohematology II, National Cancer Institute, Klenová 1, 83310, Bratislava, Slovakia.
Michaela LeitnerovaDepartment of Medical Genetics, National Cancer Institute, Bratislava, Slovakia.
Jan GyarfasDepartment of Laboratory Hematology, National Cancer Institute, Bratislava, Slovakia.
Andrea MlcakovaDepartment of Laboratory Hematology, National Cancer Institute, Bratislava, Slovakia.
Peter SzepeDepartment of Pathology, Jessenius Faculty of Medicine, The Comenius University, Martin, Slovakia.
Lukas PlankDepartment of Pathology, Jessenius Faculty of Medicine, The Comenius University, Martin, Slovakia.
Ludmila DemitrovicovaDepartment of Oncohematology II, National Cancer Institute, Klenová 1, 83310, Bratislava, Slovakia.
Vanda MikudovaDepartment of Oncohematology II, National Cancer Institute, Klenová 1, 83310, Bratislava, Slovakia.
Silvia CingelovaDepartment of Oncohematology II, National Cancer Institute, Klenová 1, 83310, Bratislava, Slovakia.
Michal Mego2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava, Slovakia.
Lubos DrgonaOncohematology Clinic, Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava, Slovakia.
Comenius University Bratislava · SKNational Institute of Cardiovascular Diseases · SKSlovak Medical University · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloid sarcoma is a rare presentation of acute leukemia as a solid tumor at various extramedullary sites. It may present concurrently, before or after the onset of systemic bone marrow leukemia. Unusual clinical localization may lead to misdiagnosis, or delayed diagnosis and treatment. We describe the first case, to our knowledge, of de novo myeloid sarcoma of the breast confirmed as acute promyelocytic leukemia. Immunohistochemical analysis, flow cytometry, fluorescent in situ hybridization analysis and molecular analysis using RQ-PCR of tissue samples should be routine in determining the correct diagnosis in this setting.

Indexed as

AdultAntineoplastic Combined Chemotherapy ProtocolsBiopsyBone MarrowBreast NeoplasmsDiagnosis, DifferentialFemaleFlow CytometryHumansImmunohistochemistryIn Situ Hybridization, FluorescenceLeukemia, Promyelocytic, AcuteMagnetic Resonance ImagingMammographySarcoma, MyeloidTreatment OutcomeAcute leukemiaDiagnosisMyelosarcomaPromyelocytic

Identifiers

PMID29931624
OpenAlexW2808762781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.