Evidence map›Paper›PMID 29931592›Full record

ReviewDrugs2018

Sarilumab: A Review in Moderate to Severe Rheumatoid Arthritis.

Yvette N Lamb, Emma D Deeks

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04345289 (Efficacy and Safety of Treatment With Convalescent Plasma for Adults With COVID-19 Pneumonia. A Double-blinded, Randomized, Multicenter Placebo-controlled Trial), which is not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04345289 phase3terminatednot on this mapstarted 2020, after this paper: background citation

Efficacy and Safety of Treatment With Convalescent Plasma for Adults With COVID-19 Pneumonia. A Double-blinded, Randomized, Multicenter Placebo-controlled Trial

TypeinterventionalSponsorThomas BenfieldRan2020 to 2021Enrolled147ConditionsCOVID, Corona Virus Infection, Viral PneumoniaArmsConvalescent anti-SARS-CoV-2 plasma, Infusion placebo
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Mechanism-based nonopioid analgesic targets.The Journal of clinical investigation · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Therapeutic Antibodies in Medicine.Molecules (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yvette N LambSpringer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. demail@springer.com.
Emma D DeeksSpringer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
Springer Nature (New Zealand) · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarilumab (Kevzara

Indexed as

AdalimumabAntibodies, Monoclonal, HumanizedAntirheumatic AgentsArthritis, RheumatoidDrug ApprovalEuropeHumansJapanMethotrexateReceptors, Interleukin-6Treatment OutcomeTumor Necrosis Factor-alphaUnited StatesAdalimumabAntibodies, Monoclonal, HumanizedAntirheumatic AgentsMethotrexateReceptors, Interleukin-6sarilumabTumor Necrosis Factor-alpha

Identifiers

PMID29931592
OpenAlexW2805472045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.