Evidence map›Paper›PMID 29931584›Full record

ArticleInvestigational new drugs2019

Alteration of benzo(a)pyrene biotransformation by resveratrol in Apc

Ashley C Huderson, P V Rekha Devi, Mohammad S Niaz, Samuel E Adunyah, Aramandla Ramesh

Abstract read
In one paragraph

Article in Investigational new drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ashley C HudersonThe American Society of Mechanical Engineers, 1828 L St. N.W, Washington, DC, 20036, USA.
P V Rekha DeviToxicology and Pharmacology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad, Telangana, 500007, India.
Mohammad S NiazDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, Meharry Medical College, 1005 D.B. Todd Blvd, Nashville, TN, 37208, USA.
Samuel E AdunyahDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, Meharry Medical College, 1005 D.B. Todd Blvd, Nashville, TN, 37208, USA.
Aramandla RameshDepartment of Biochemistry, Cancer Biology, Neuroscience & Pharmacology, Meharry Medical College, 1005 D.B. Todd Blvd, Nashville, TN, 37208, USA. aramesh@mmc.edu.
Meharry Medical College · USAmerican Society of Mechanical Engineers · USIndian Institute of Chemical Technology · IN

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2M
Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION: NEUROSCIC06RR022072 · NCRR · MEHARRY MEDICAL COLLEGE · PI LIMA, MARIA F · 2005 to 2005
$4.0M
Minority Institution Research Training ProgramT32HL007735 · NHLBI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 1992 to 2014
$2.9M
Mechanisms for Benzo(a)pyrene-Induced Colon Cancer Exacerbation by Dietary FatR01CA142845 · NCI · MEHARRY MEDICAL COLLEGE · PI RAMESH, ARAMANDLA · 2010 to 2013
$1.2M
Chemoprevention of benzo(a)pyrene-induced colon carcinogenesisF31ES019432 · NIEHS · MEHARRY MEDICAL COLLEGE · PI HUDERSON, ASHLEY CORRIN · 2011 to 2012
$55k
NCI NIH HHS R01 CA142845NCI NIH HHS U54 CA163069NCRR NIH HHS C06 RR022072NHLBI NIH HHS T32 HL007735NIEHS NIH HHS F31 ES019432NIGMS NIH HHS R25 GM059994NIH HHS G12RR003022NIMHD NIH HHS U54 MD007586NIMHD NIH HHS U54 MD007593
6 · The paper itself

Abstract

Epidemiological surveys have revealed that environmental and dietary factors contribute to most of the human cancers. Our earlier studies have shown that resveratrol (RVT), a phytochemical reduced the tumor number, size and incidence of dysplasias induced by benzo(a)pyrene (BaP), an environmental toxicant in the Apc

Indexed as

Disease Models, AnimalAnimalsAntioxidantsApoptosisBenzo(a)pyreneBiotransformationCarcinogenesisCarcinogens, EnvironmentalCell ProliferationColonic NeoplasmsCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA AdductsGene Expression Regulation, NeoplasticGlutathione TransferaseHumansAntioxidantsBenzo(a)pyrenebenzo(a)pyrene-DNA adductCarcinogens, EnvironmentalCyp1a1 protein, mouseCyp1b1 protein, mouseCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA AdductsGlutathione TransferaseResveratrolApcMin/+ mouseBenzo(a)pyreneBiotransformationChemopreventionColon carcinogenesisResveratrol

Identifiers

PMID29931584
PMCPMC6309585
OpenAlexW2809529985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.