Evidence map›Paper›PMID 29931565›Full record

ReviewJournal of experimental orthopaedics2018

Nonoperative treatment of muscle injuries - recommendations from the GOTS expert meeting.

T Hotfiel, R Seil, W Bily, W Bloch, A Gokeler, R M Krifter, F Mayer, P Ueblacker, L Weisskopf, M Engelhardt

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of experimental orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07566039 (Prospective Cohort Study of Athletes Following an Injection of Platelet-Poor Plasma Into an Acute Muscle Injury), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07566039 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective Cohort Study of Athletes Following an Injection of Platelet-Poor Plasma Into an Acute Muscle Injury

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2030Enrolled90ConditionsLower Extremity InjuryArmsPlatelet Poor Plasma (PPP) Injection
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Injection therapy in professional footballers.International orthopaedics · 2024
    Review
  8. Article
  9. Article
  10. Medial Gastrocnemius Strain: Clinical Aspects and Algorithmic Approach.Medical journal of the Islamic Republic of Iran · 2024
    Article
  11. Traumatic muscle injury.Nature reviews. Disease primers · 2023
    Review
  12. Shaping experimental orthopaedics.Journal of experimental orthopaedics · 2023
    Article
  13. Management of anterior thigh injuries in soccer players: practical guide.BMC sports science, medicine & rehabilitation · 2022
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Actovegin® reduces PMA-induced inflammation on human cells.European journal of applied physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 4 countries.

T HotfielDepartment of Orthopaedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Rathsbergerstraße 57, D-91054, Erlangen, Germany. Thilo.Hotfiel@fau.de.
R SeilDepartment of Orthopaedic Surgery, Clinique d'Eich - Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
W BilyDepartment of Physical Medicine and Rehabilitation, Wilhelminenspital, Vienna, Austria.
W BlochDepartment of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
A GokelerLuxembourg Institute of Research in Orthopedics, Sports Medicine and Science, Luxembourg City, Luxembourg.
R M KrifterORTHOFOCUS-Orthopedic Competence Center, Graz-Salzburg, Austria.
F MayerOutpatient Clinic Potsdam, Sports Medicine & Sports Orthopaedics, University of Potsdam, Potsdam, Germany.
P UeblackerMW Center of Orthopedics and Sports Medicine, Munich, Germany.
L WeisskopfAltius Swiss Sportmed Center, Rheinfelden, Switzerland.
M EngelhardtDepartment of Trauma and Orthopedic Surgery, Klinikum Osnabrück, Osnabrück, Germany.
Centre Hospitalier de Luxembourg · LUFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Sport University Cologne · DEInstitute for Sports Medicine · DEKlinikum Osnabrück · DEPaderborn University · DEReha Rheinfelden · CHUnfallkrankenhaus Salzburg · ATUniversity of Potsdam · DEWilhelminen Hospital · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMuscle injuries are some of the most common injuries in sports; they have a high recurrence rate and can result in the loss of ability to participate in training or competition. In clinical practice, a wide variety of treatment strategies are commonly applied. However, a limited amount of evidence-based data exists, and most therapeutic approaches are solely based on "best practice". Thus, there is a need for consensus to provide strategies and recommendations for the treatment of muscle injuries.

methodsThe 2016 GOTS Expert Meeting, initiated by the German-Austrian-Swiss Society for Orthopaedic Traumatologic Sports Medicine (GOTS), focused on the topic of muscle and tendon injuries and was held in Spreewald/Berlin, Germany. The committee was composed of twenty-two medical specialists. Nine of them were delegated to a subcommittee focusing on the nonoperative treatment of muscle injuries. The recommendations and statements that were developed were reviewed by the entire consensus committee and voted on by the members.

resultsThe committee reached a consensus on the utility and effectiveness of the management of muscle injuries. MAIN

resultsthe "PRICE" principle to target the first inflammatory response is one of the most relevant steps in the treatment of muscle injuries. Haematoma aspiration may be considered in the early stages after injury. There is presently no clear evidence that intramuscular injections are of use in the treatment of muscle injuries. The ingestion of non-steroidal anti-inflammatory drugs (NSAIDs) should be regarded critically because there is currently no hard evidence to support their use, although they are appropriate in exceptional cases.

conclusionsThe present work provides a structured overview of the various nonoperative treatment strategies of muscle injuries and evaluates their effectiveness with respect to the existing scientific evidence and clinical expertise in the context of basic science on the healing process of muscle injuries. The committee agreed that there is a compelling need for further studies, including high-quality randomized investigations to completely evaluate the effectiveness of the existing therapeutic approaches. The given recommendations may be updated and adjusted as further evidence will be generated.

Indexed as

ActoveginConsensus statementInjectionMuscle injuriesMuscle strainPRICEPRPSports injuriesTreatment

Identifiers

PMID29931565
PMCPMC6013414
OpenAlexW2809048735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.