ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2019
Therapy of aseptic nonunions with parathyroid hormone.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies.Bone research · 2026Review
- Optimizing type H vessels formationBioactive materials · 2025Article
- Teriparatide as a non-surgical salvage therapy for prolonged humerus fracture nonunion: A case report and literature review.World journal of orthopedics · 2025Article
- Multiple fractures after low-energy trauma in an immunosuppressed lung transplant patient with severe osteoporotic bone texture-a challenge for traumatology and osteology.Journal of surgical case reports · 2024Article
- Article
- Efficacy and Safety of Teriparatide in Improving Fracture Healing and Callus Formation: A Systematic Review.Cureus · 2023Review
- Use of Teriparatide in preventing delayed bone healing and nonunion: a multicentric study on a series of 20 patients.BMC musculoskeletal disorders · 2023Article
- Complete bone fusion in failed back surgery syndrome using teriparatide in neurosyphilis: A case report.International journal of surgery case reports · 2022Article
- Treatment of postoperative non-union with internal fixation loosening of Garden IV femoral neck fracture with teriparatide in a young adult: A case report.Frontiers in surgery · 2022Article
- Article
- Present and future scope of recombinant parathyroid hormone therapy in orthopaedics.Journal of clinical orthopaedics and trauma · 2021Review
- Scope and Limits of Teriparatide Use in Delayed and Nonunions: A Case Series.Clinics and practice · 2021Article
- The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.Bone reports · 2020Review
- Teriparatide for treating delayed union and nonunion: A systematic review.Journal of clinical orthopaedics and trauma · 2020Review
- Correlation of serum PTH level and fracture healing speed in elderly patients with hip fracture.Journal of orthopaedic surgery and research · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The absence of osseous consolidation of a fracture for 9 or more months with no potential to heal is defined as nonunion. Both for the patient and from a socioeconomic point of view, nonunions represent a major problem. Hypertrophic, vital nonunions are distinguished from atrophic avital ones. Risk factors for a delayed fracture healing are insufficient immobilisation, poor adaptation of the fracture surfaces or residual instability, interposition of soft tissue within the fracture gap, as well as circulation disturbances and infections. The incidence of nonunions after fractures of the long bones lies between 2.6 and 16% depending on the surgical technique used. In human and animal studies, a positive effect of parathyroid hormone (PTH) on fracture healing has been shown. PTH has a direct stimulatory effect on osteoblasts and osteoclasts. In addition, it appears to influence the effect of osseous growth factors. In this prospective study, 32 patients with nonunions were treated with teriparatide to investigate the effects of PTH on fracture healing. Definitive healing of the nonunions following PTH treatment could be observed in 95% of the cases.
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