Evidence map›Paper›PMID 29931424›Full record

ArticleActa diabetologica2018

Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia.

David Harry McDougal, Moses Morakortoi Darpolor, Marina Andreyevna DuVall, Elizabeth Frost Sutton, Christopher David Morrison, Kishore Murali Gadde, Leanne Maree Redman, Owen Thomas Carmichael

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02690168 (Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02690168 completednot on this map

Testing Glial Pathways to HAAF in Human Subjects Using Carbon 13 Magnetic Resonance Spectroscopy

TypeobservationalSponsorPennington Biomedical Research CenterRan2016 to 2017Enrolled6ConditionsDiabetes Complications, HypoglycemiaArmsFasting
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

David Harry McDougalPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA. David.McDougal@pbrc.edu.ORCID http://orcid.org/0000-0003-4243-4897
Moses Morakortoi DarpolorPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Marina Andreyevna DuVallPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Elizabeth Frost SuttonPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Christopher David MorrisonPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Kishore Murali GaddePennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Leanne Maree RedmanPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Owen Thomas CarmichaelPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Pennington Biomedical Research Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2005 to 2026
$26.5M
Louisiana Nutrition Obesity Research Center P30 DK072476National Institute of General Medical Sciences of the National Institutes of Health 1 U54 GM104940NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

aimsPrior exposure to insulin-induced hypoglycemia was shown to increase glial acetate metabolism (GAM) during subsequent exposure to hypoglycemia in diabetic individuals. However, it remained unclear whether this effect was dependent on the disease state or the antecedent cause of hypoglycemia. We aimed to establish whether exposure to fasting-induced hypoglycemia was sufficient to produce alterations in GAM in non-diabetic individuals.

methodsGAM was measured via carbon-13 magnetic resonance spectroscopy during infusion of [1-

resultsAs expected, 72 h of fasting significantly reduced blood glucose levels and resulted in a high frequency of hypoglycemic episodes. Steady-state GAM increased from 53.5 ± 3.7 to 61.9 ± 1.7% following the 72-h fast (p = 0.005). This increase correlated with greater duration of hypoglycemia experienced during the fast (r = 0.967). In addition, subjects with greater GAM at baseline experienced a greater increase in the duration of hypoglycemia experienced during the 72-h fast (r = 0.979).

conclusionsGAM has potential as a biomarker for susceptibility to hypoglycemic episodes. TRAIL REGISTRATION: Clinicaltrials.gov ID: NCT02690168.

Indexed as

AcetatesAdolescentAdultBlood GlucoseBlood Glucose Self-MonitoringDisease SusceptibilityFastingFemaleHumansHypoglycemiaInsulinMaleNeurogliaYoung AdultAcetatesBlood GlucoseInsulinAcetatesFastingGlucoseHumansHypoglycemiaMagnetic resonance spectroscopyNeuroglia

Identifiers

PMID29931424
PMCPMC6153507
OpenAlexW2808802633

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.