Evidence map›Paper›PMID 29931417›Full record

ArticleSkeletal radiology2018

Correlation of benign incidental findings seen on whole-body PET-CT with knee MRI: patterns of

Christopher J Burke, William R Walter, Sushma Gaddam, Hien Pham, James S Babb, Joseph Sanger, Fabio Ponzo

Abstract read
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In one paragraph

Article in Skeletal radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Use of bone-SPECT/CT and Na[Frontiers in nuclear medicine · 2025
    Review
  4. Article
  5. MRI of synovitis and joint fluid.Journal of magnetic resonance imaging : JMRI · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christopher J BurkeDepartment of Radiology, NYU Langone Orthopedic Hospital, 301 E 17th St, New York, NY, 10003, USA. christopher.burke@nyumc.org.
William R WalterDepartment of Radiology, NYU Langone Orthopedic Hospital, 301 E 17th St, New York, NY, 10003, USA.
Sushma GaddamDepartment of Radiology, NYU Langone Orthopedic Hospital, 301 E 17th St, New York, NY, 10003, USA.
Hien PhamDepartment of Orthopedic Surgery, NYU Hospital for Joint Diseases, Center for Musculoskeletal Care, 301 E 17th St, New York, NY, 10003, USA.
James S BabbDepartment of Statistics, NYU Langone Medical Center, 660 1st Avenue, New York, NY, 10016, USA.
Joseph SangerDepartment of Nuclear Medicine, NYU Langone Medical Center, 560 1st Avenue, New York, NY, 10016, USA.
Fabio PonzoDepartment of Nuclear Medicine, NYU Langone Medical Center, 560 1st Avenue, New York, NY, 10016, USA.
New York University Langone Orthopedic Hospital · USNYU Langone Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo correlate patterns of MATERIALS AND

methodsRetrospective database query was performed using codes for knee MRI as well as whole-body PET-CT. Patients with malignant disease involving the knee or hardware were excluded. Patients who had both studies performed within 1 year between 2012 and 2017 were included for analysis. Knee joint osteoarthrosis, meniscal and ligamentous integrity, presence of joint effusion, and synovitis were assessed and recorded. Bone marrow edema lesions (BMELs) were identified, segmented, and analyzed using volumetric analysis. SUVmax was assessed over the suprapatellar joint space, intercondylar notch and Hoffa's fat pad. Symptomatic and asymptomatic knees were compared in patients with unilateral symptoms.

resultsTwenty-two cases (20 patients) with mean age 63.3 years (range, 36-91 years) were included. Two patients had bilateral pain. The most FDG avid regions in both symptomatic and asymptomatic knees were the intercondylar notch (SUVmax = 1.84 vs. 1.51), followed by suprapatellar pouch (SUVmax = 1.74 vs. 1.29) and Hoffa's fat pad (SUVmax = 1.01 vs. 0.87). SUVmax was significantly associated with cartilage loss (mean modified Outerbridge score) (r = 0.60, p = 0.003) and degree of synovitis (r = 0.48, p = 0023). Overall, mean SUVmax was significantly higher in the presence of a meniscal tear (1.83 ± 0.67 vs. 1.22 ± 0.40, p = 0.030). Nine patients had BMELs (volume: range = 0.6-27.8, mean = 7.79) however there was no significant association between BMEL volume and SUVmax.

conclusionsHigher FDG activity correlates with intra-articular derangement and the intercondylar notch represents the most metabolically active region of the knee.

Indexed as

Incidental FindingsMagnetic Resonance ImagingPositron Emission Tomography Computed TomographyWhole Body ImagingAdultAgedAged, 80 and overBone Marrow DiseasesEdemaFemaleFluorodeoxyglucose F18HumansJoint DiseasesKnee JointMaleMiddle AgedFluorodeoxyglucose F18Radiopharmaceuticals18F-FDGKneeKnee jointMagnetic resonance imagingMusculoskeletal ultrasoundPositron emission tomography

Identifiers

PMID29931417
OpenAlexW2809305861

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.