ArticleThe journal of headache and pain2018
Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study.
Article in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pooled it
- Diffusion Tensor Imaging as a Tool to Evaluate the Cognitive Function of Patients With Vascular Dementia: A Meta-Analysis.The neurologist · 2023Pooled it
- Associations Between Multiple Chemosensory Dysfunction and Cognition.International forum of allergy & rhinology · 2026Article
- Fixel‑based analysis reveals distributed white matter alterations associated with pain severity in trigeminal neuralgia.The journal of headache and pain · 2026Article
- Glymphatic system bridges peripheral and central nervous system changes in classic trigeminal neuralgia.Brain communications · 2026Article
- Pain-side-specific alteration of structural networks in trigeminal neuralgia: a connectome analysis.Frontiers in neuroscience · 2026Article
- Article
- Network control theory uncovers aberrant connectome controllability in trigeminal neuralgia.The journal of headache and pain · 2025Article
- Can Pain Neuroscience Education Combined with Cognition-Targeted Exercise Therapy Change White Matter Structure in People with Chronic Spinal Pain? A Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Altered white matter microstructural integrity in patients with postherpetic neuralgia: a combined DTI and DTI-NODDI study.Frontiers in neuroscience · 2025Article
- Altered structure and functional connection of subcortical gray matter in female patients with classical trigeminal neuralgia.Brain imaging and behavior · 2024Article
- Review
- A novel indicator to predict the outcome of percutaneous stereotactic radiofrequency rhizotomy for trigeminal neuralgia patients: diffusivity metrics of MR-DTI.Scientific reports · 2024Article
- Altered trends of local brain function in classical trigeminal neuralgia patients after a single trigger pain.BMC medical imaging · 2024Article
- White matter microstructure alterations in type 2 diabetes mellitus and its correlation with cerebral small vessel disease and cognitive performance.Scientific reports · 2024Article
- The white matter characteristic of the genu of corpus callosum coupled with pain intensity and negative emotion scores in patients with trigeminal neuralgia: a multivariate analysis.Frontiers in neuroscience · 2024Article
- Enhanced Integrity of White Matter Microstructure in Mind-Body Practitioners: A Whole-Brain Diffusion Tensor Imaging Study.Brain sciences · 2023Article
- Alteration of brain network centrality in CTN patients after a single triggering pain.Frontiers in neuroscience · 2023Article
- Brain entropy changes in classical trigeminal neuralgia.Frontiers in neurology · 2023Article
- Research on the Mechanism of Cognitive Decline in Patients With Acoustic Neuroma.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIdiopathic or classical trigeminal neuralgia (TN) is a chronic painful condition characterized by intermittent pain attacks. Enough evidence demonstrates classical TN is related to neurovascular compression (NVC) at the trigeminal root entry zone (REZ), but white matter change secondary to TN are not totally known.
methodsVisual Analogue Scale (VAS) and diffusion tensor imaging were performed on 29 patients with right TN and 35 healthy individuals. Voxel-wise analyses were performed with TBSS using multiple diffusion metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). Group differences in these parameters were compared between right TN patients and controls using TBSS and correlations between the white matter change and disease duration and VAS in right TN patients were assessed. Multiple comparison correction were applied to test significant correlations.
resultsThe right TN patients showed significantly lower FA and higher RD in most left white matter (P < 0.05, FWE corrected). Moreover, negative correlations were observed between disease duration and the FA values of left corona radiata, genu of corpus callosum, left external capsule and left cerebral peduncle, and between VAS and the FA values of left corona radiata, left external capsule and left cerebral peduncle (P < 0.05). Positive correlations were observed for disease duration and the RD values of left corona radiata, right external capsule, left fornix cerebri and left cerebral peduncle, and for VAS and the RD values of left corona radiata and left external capsule (P < 0.05). However, once Bonferroni corrections were applied, these correlations were not statistically significant.
conclusionThese findings suggest that TN selectively impairs widespread white matter, especially contralateral hemisphere, which may be the hallmark of disease severity in TN patients.
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