ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Type 2 Diabetes Mellitus Is Associated with the Risk of Cognitive Impairment: a Meta-Analysis.Journal of molecular neuroscience : MN · 2019Pooled it
- Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.JAMA network open · 2026Article
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- Pathway analysis of cognitive resilience factors and cognitive function in the Long Life Family Study (LLFS).Neuropsychology · 2026Observational
- Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study.International journal of environmental research and public health · 2023Observational
- Single-Cell Transcriptomics Reveals Longevity Immune Remodeling Features Shared by Centenarians and Their Offspring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- No Evidence That Genetic Variation at the Klotho Locus Is Associated With Longevity in Caucasians from the Newcastle 85+ Study and the UK Biobank.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Aging-related Resiliency Theory Development.Belitung nursing journal · 2022Article
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- Digital Technology Differentiates Graphomotor and Information Processing Speed Patterns of Behavior.Journal of Alzheimer's disease : JAD · 2021Article
- APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age.Journal of Alzheimer's disease : JAD · 2021Observational
- The Role of Cyclooxygenase 2 in the Cognitive Impairment Induced by Alcohol or Stress in Rats.Advanced biomedical research · 2021Article
- Informal Caregiving, Poor Mental Health, and Subjective Cognitive Decline: Results From a Population-Based Sample.Journal of gerontological nursing · 2020Article
- The relationship of parental longevity with the aging brain-results from UK Biobank.GeroScience · 2020Article
- Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.GeroScience · 2020Article
- Centenarians as Models of Resistance and Resilience to Alzheimer's Disease and Related Dementias.Advances in geriatric medicine and research · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Background: Centenarian offspring have better health and lower mortality in comparison to referent cohorts, however it is unknown whether they have preserved cognition at older ages. Methods: This prospective study of 491 centenarian offspring and 270 referent participants without familial longevity (mean baseline age 75.5 years) from the New England Centenarian Study analyzed longitudinal cognitive assessments performed using the Telephone Interview for Cognitive Status. Logistic regression was used for cognitive impairment at baseline and Cox proportional hazards regression for risk of incident cognitive impairment. Results: After adjustment for age, sex, education, stroke, and diabetes, offspring were 46% less likely to have baseline cognitive impairment (adjusted odds ratio 0.54, 95% CI 0.35-0.82) and were 27% less likely to become cognitively impaired over a median follow-up of 7.8 years (adjusted hazard ratio 0.73, 95% CI 0.53-0.99). Female gender was also independently associated with lower odds of baseline cognitive impairment and lower risk of incident cognitive impairment. Conclusions: Familial longevity may confer exposure to genetic and environmental factors that predispose centenarian offspring to preservation of cognitive function at older ages. Centenarian offspring cohorts may provide an opportunity to study cognitive resilience associated with familial longevity.
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