Evidence map›Paper›PMID 29931085›Full record

ArticleBioinformatics (Oxford, England)2019

htsget: a protocol for securely streaming genomic data.

Jerome Kelleher, Mike Lin, C H Albach, Ewan Birney, Robert Davies, Marina Gourtovaia, David Glazer, Cristina Y Gonzalez, David K Jackson, Aaron Kemp and 7 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Analysis-ready VCF at Biobank scale using Zarr.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. A general and efficient representation of ancestral recombination graphs.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. The European Genome-phenome Archive in 2021.Nucleic acids research · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jerome KelleherBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Mike LinDNAnexus, 1975 West El Camino Real, Suite 101, Mountain View, CA, USA.
C H AlbachVerily Life Sciences LLC, 269 East Grand Avenue, South San Francisco, CA, USA.
Ewan BirneyEuropean Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
Robert DaviesWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Marina GourtovaiaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
David GlazerVerily Life Sciences LLC, 269 East Grand Avenue, South San Francisco, CA, USA.
Cristina Y GonzalezEuropean Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
David K JacksonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Aaron KempGoogle Inc.
John MarshallWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Andrew NowakWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Alexander SenfEuropean Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
Jaime M Tovar-CoronaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Alexander VikhorevEuropean Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
Thomas M KeaneEuropean Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
GA4GH Streaming Task Team

Funding

Wellcome Trust 100956/Z/13/ZWellcome Trust 201535/Z/16/Z
6 · The paper itself

Abstract

Summary: Standardized interfaces for efficiently accessing high-throughput sequencing data are a fundamental requirement for large-scale genomic data sharing. We have developed htsget, a protocol for secure, efficient and reliable access to sequencing read and variation data. We demonstrate four independent client and server implementations, and the results of a comprehensive interoperability demonstration. Availability and implementation: http://samtools.github.io/hts-specs/htsget.html. Supplementary information: Supplementary data are available at Bioinformatics online.

Indexed as

Computational BiologyGenomicsHigh-Throughput Nucleotide SequencingSoftwareGenome

Identifiers

PMID29931085
PMCPMC6298043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.