ArticleLab on a chip2018
An acoustofluidic trap and transfer approach for organizing a high density single cell array.
Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Single-Cell RNA Sequencing in Organ and Cell Transplantation.Biosensors · 2024Review
- Magnetophoretic circuits: A review of device designs and implementation for precise single-cell manipulation.Analytica chimica acta · 2023Review
- Magnetophoretic capacitors for storing single particles and magnetized cells in microfluidic devices.Biomicrofluidics · 2022Article
- High-throughput precise particle transport at single-particle resolution in a three-dimensional magnetic field for highly sensitive bio-detection.Scientific reports · 2022Article
- Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses.Science advances · 2021Article
- Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review.Micromachines · 2021Review
- Injection Molded Microfluidics for Establishing High-Density Single Cell Arrays in an Open Hydrogel Format.Analytical chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We demonstrate a hybrid microfluidic system that combines fluidic trapping and acoustic switching to organize an array of single cells at high density. The fluidic trapping step is achieved by balancing the hydrodynamic resistances of three parallel channel segments forming a microfluidic trifurcation, the purpose of which was to capture single cells in a high-density array. Next, the cells were transferred into adjacent larger compartments by generating an array of streaming micro-vortices to move the cells to the desired streamlines in a massively parallel format. This approach can compartmentalize single cells with efficiencies of ≈67% in compartments that have diameters on the order of ∼100 um, which is an appropriate size for single cell proliferation studies and other single cell biochemical measurements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.