Evidence map›Paper›PMID 29930990›Full record

ArticlePathogens & immunity2018

Variation in Macrophage Phagocytosis of

Lisa M Rogers, Jennifer A Gaddy, Shannon D Manning, David M Aronoff

Open access · diamondAbstract read
In one paragraph

Article in Pathogens & immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Comparison of cytokine responses to group BInfection and immunity · 2025
    Article
  2. Article
  3. Specific interaction between Group BInfection and immunity · 2024
    Article
  4. Macrophage polarization duringFrontiers in microbiology · 2023
    Article
  5. Article
  6. Distinct Group BInfection and immunity · 2021
    Article
  7. Uvaol Prevents Group BFrontiers in physiology · 2021
    Article
  8. Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus.American journal of reproductive immunology (New York, N.Y. : 1989) · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lisa M RogersDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Jennifer A GaddyDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Shannon D ManningDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan.
David M AronoffDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USMichigan State University · US

Funding

Determining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5M
The Role of macrophages in chorioamnionitis and group B streptococcal infectionsR01AI134036 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M · 2017 to 2021
$2.4M
NIAID NIH HHS R01 AI134036NICHD NIH HHS R01 HD090061
6 · The paper itself

Abstract

backgroundGroup B

methodsA high-throughput screen using the phorbol ester-differentiated THP-1 macrophage-like human cell line was used to quantify phagocytosis of a diverse group of 35 different human clinical isolates of GBS representing a wide variety of capsular serotypes. Validation studies were conducted using human primary phagocytes.

resultsPhagocytosis of GBS differed widely across clinical isolates but this was not related to capsular serotype, genetic sequence type, pilus type, or clinical source of the GBS isolate (colonizing or invasive strain).

conclusionsStructural and/or biochemical differences among diverse GBS strains are reflected in a diverse capacity for macrophages to ingest them through non-opsonic phagocytosis. Mechanisms explaining these differences are not clear.

Indexed as

diabetesGram-positive bacteriainnate immunitymacrophagesNeonatal sepsis

Identifiers

PMID29930990
PMCPMC6007880
OpenAlexW2803882958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.