Evidence map›Paper›PMID 29930750›Full record

ArticleOncotarget2018

LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice.

Eloise Ferreira, Monique J Bignoux, Tyrone C Otgaar, Nicolas Tagliatti, Katarina Jovanovic, Boitelo T Letsolo, Stefan F T Weiss

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. TheFrontiers in neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Eloise FerreiraSchool of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Monique J BignouxSchool of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Tyrone C OtgaarSchool of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Nicolas TagliattiSchool of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Katarina JovanovicSchool of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Boitelo T LetsoloSchool of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Stefan F T WeissSchool of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
University of the Witwatersrand · ZAUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease caused by accumulation of amyloid beta (Aβ) plaque and neurofibrillary tangle formation. We have shown

Indexed as

Alzheimer’s diseaseamyloid betaLRP-LRtherapeutic antibodytransgenic mice

Identifiers

PMID29930750
PMCPMC6007457
OpenAlexW2805427998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.