Evidence map›Paper›PMID 29930745›Full record

ArticleOncotarget2018

Quality of life in cancer patients undergoing anticoagulant treatment with LMWH for venous thromboembolism: the QUAVITEC study on behalf of the Groupe Francophone Thrombose et Cancer (GFTC).

Dominique Farge, Francis Cajfinger, Nicolas Falvo, Toufek Berremili, Francis Couturaud, Okba Bensaoula, Lionel Védrine, Hocine Bensalha, Isabelle Bonnet, Denis Péré-Vergé and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Direct oral anticoagulantsWorld journal of methodology · 2026
    Article
  3. Review
  4. Quality of life in oncological patients with venous thromboembolic disease.Research and practice in thrombosis and haemostasis · 2024
    Review
  5. Pulmonary embolism in cancer patients. Effectiveness of vitamin K antagonists and direct oral anticoagulants in long-term therapy.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2024
    Review
  6. Pancreatic Cancer and Venous Thromboembolism.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Cancer-associated venous thromboembolism.Nature reviews. Disease primers · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 2 countries.

Dominique FargeAssistance Publique-Hopitaux de Paris, Saint-Louis Hospital, Internal Medicine, Autoimmune and Vascular Disease Unit, UF 04, Diderot University, Paris, France.
Francis CajfingerMedical Oncology, Hôpital Pitié-Salpêtrière, Paris, France.
Nicolas FalvoDépartement de Pathologie Vasculaire, CHU Dijon, Dijon Cedex, France.
Toufek BerremiliDepartment of Cardiology, Annecy Hospital, Annecy, France.
Francis CouturaudBrest University Hospital, CHU de Brest, Brest, France.
Okba BensaoulaDepartment of Oncology, CLCC Curie Institute, Centre Rene Huguenin, Saint Cloud, France.
Lionel VédrineHôpital d'Instruction des Armées du Val-de-Grâce, Paris, France.
Hocine BensalhaAssistance Publique-Hopitaux de Paris, Saint-Louis Hospital, Internal Medicine, Autoimmune and Vascular Disease Unit, UF 04, Diderot University, Paris, France.
Isabelle BonnetDepartment of Oncology, Hospital of Valenciennes, Valenciennes, France.
Denis Péré-VergéCH Saint Joseph Saint Luc, Lyon, France.
Marie CoudurierChambéry CH, Chambéry, France.
Veronique LiCH Thonon-Les-Bains, Thonon-les-Bains, France.
Hanadi RafiiAssistance Publique-Hopitaux de Paris, Saint-Louis Hospital, Internal Medicine, Autoimmune and Vascular Disease Unit, UF 04, Diderot University, Paris, France.
Ilham BenzidiaAssistance Publique-Hopitaux de Paris, Saint-Louis Hospital, Internal Medicine, Autoimmune and Vascular Disease Unit, UF 04, Diderot University, Paris, France.
Jean M ConnorsHematology Division, Harvard Medical School, Boston, MA, USA.
Matthieu Resche-RigonService de Biostatistique et Information Médicale, AP-HP Hôpital Saint-Louis, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Annecy Genevois · FRCentre Hospitalier de Valenciennes · FRCentre Hospitalier Métropole Savoie · FRCentre Hospitalier Régional Universitaire de Brest · FRCentre Hospitalier Saint-Joseph Saint-Luc · FRCentre Hospitalier Universitaire Dijon Bourgogne · FRDélégation Paris 7 · FRHarvard University · USHIA du Val-de-Grâce à Paris · FRHôpital René Huguenin · FRHôpital Saint-Louis · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical guidelines recommend at least 3-months low molecular weight heparin (LMWH) treatment for established venous thromboembolism (VTE) in cancer patients. However, no study has analyzed the impact of 3-6 months of LMWH therapy on quality-of-life (QoL) in cancer patients.

resultsAmong 400 cancer patients included at M0, 88.8% received long-term LMWH. Using a random-effects linear regression model with time as covariate, QoL scores in the MOS SF-36 (Global HRQoL, 1.3-fold per month [95% confidence interval (CI) 0.81-1.79],

methodsQUAVITEC, a prospective, longitudinal, multicenter study, recruited all consecutive eligible adult cancer patients with objectively confirmed VTE between February 2011 and 2012. Patients were asked to answer three QoL questionnaires at anticoagulant treatment initiation (M0) and at 3 (M3) and 6 (M6)-month follow-ups.

conclusionQUAVITEC is the first study to show that QoL was improved in cancer patients receiving long-term LMWH treatment for established VTE.

Indexed as

anticoagulation therapycancer thrombosisLMWHquality of lifevenous thromboembolism

Identifiers

PMID29930745
PMCPMC6007467
OpenAlexW2807567255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.