Evidence map›Paper›PMID 29930736›Full record

ArticleTheranostics2018

Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions.

Pedram Heidari, Anchisa Kunawudhi, Jordi Martinez-Quintanilla, Alicia Szretter, Khalid Shah, Umar Mahmood

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Approaches to Imaging Immune Activation Using PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. OncoTargets and therapy · 2020
    Article
  12. Separation ofMolecules (Basel, Switzerland) · 2018
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pedram HeidariDepartment of Radiology, Massachusetts General Hospital, Boston, MA.
Anchisa KunawudhiDepartment of Radiology, Massachusetts General Hospital, Boston, MA.
Jordi Martinez-QuintanillaDepartment of Radiology, Massachusetts General Hospital, Boston, MA.
Alicia SzretterDepartment of Radiology, Massachusetts General Hospital, Boston, MA.
Khalid ShahDepartment of Radiology, Massachusetts General Hospital, Boston, MA.
Umar MahmoodDepartment of Radiology, Massachusetts General Hospital, Boston, MA.
Massachusetts General Hospital · US

Funding

PET imaging of carcinoid tumors to guide individualized chemotherapyR01CA166582 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAHMOOD, UMAR · 2013 to 2017
$1.8M
NCI NIH HHS R01 CA166582
6 · The paper itself

Abstract

Reporter gene systems can serve as therapy targets. However, the therapeutic use of reporters has been limited by the challenges of transgene delivery to a majority of cancer cells. This study specifically assesses the efficacy of targeting human somatostatin receptor subtype 2 (hSSTR2) with peptide receptor radionuclide therapy (PRRT) when a small subpopulation of cells bears the transgene.

Indexed as

A549 CellsAnimalsAntineoplastic AgentsBiomarkers, TumorDisease Models, AnimalGenes, ReporterHeterograftsHumansMesenchymal Stem CellsMice, NudeMolecular Targeted TherapyNeoplasm TransplantationOctreotidePancreatic NeoplasmsPositron-Emission TomographyRadiopharmaceuticals90Y-octreotide, DOTA-Tyr(3)-Antineoplastic AgentsBiomarkers, TumorOctreotideRadiopharmaceuticalsReceptors, Somatostatinsomatostatin receptor 268Ga-DOTATOCpeptide receptor radionuclide therapy (PRRT)reporter genesomatostatin receptortheranostic

Identifiers

PMID29930736
PMCPMC6010996
OpenAlexW2805640388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.