ReviewChinese medicine2018
Cellular stress response mechanisms of Rhizoma coptidis: a systematic review.
Review in Chinese medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Coptidis Rhizoma extract mitigates sleep deprivation-induced cognitive impairment and neurodegeneration: Insights into hormonal, glymphatic, and molecular mechanisms.Journal of traditional and complementary medicine · 2026Article
- Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus.Stem cell research & therapy · 2025Review
- Exploring the patterns in traditional Chinese medicine for bipolar disorder: a data-driven network approach.Frontiers in pharmacology · 2025Article
- Exploring the therapeutic mechanisms of Coptidis Rhizoma in gastric precancerous lesions: a network pharmacology approach.Discover oncology · 2024Article
- A breakthrough in phytochemical profiling: ultra-sensitive surface-enhanced Raman spectroscopy platform for detecting bioactive components in medicinal and edible plants.Mikrochimica acta · 2024Article
- Alisol A, the Eye-Entering Ingredient ofDrug design, development and therapy · 2024Article
- Article
- Natural phytochemicals that affect autophagy in the treatment of oral diseases and infections: A review.Frontiers in pharmacology · 2022Review
- Effects of a Mixture of Ivy Leaf Extract andInternational journal of environmental research and public health · 2021Observational
- Antifungal activity and potential mechanism of magnoflorine against Trichophyton rubrum.The Journal of antibiotics · 2021Article
- Inhibition of oxidative stress induced-cytotoxicity by coptisine in V79-4 Chinese hamster lung fibroblasts through the induction of Nrf-2 mediated HO-1 expression.Genes & genomics · 2021Article
- The Potential Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Network Pharmacology-Based Analysis and Experimental Exploration of Antidiabetic Mechanisms of Gegen Qinlian Decoction.Frontiers in pharmacology · 2021Article
- Dissecting and Evaluating the Therapeutic Targets of Coptis Chinensis Franch in the Treatment of Urinary Tract Infections Induced byFrontiers in pharmacology · 2021Article
- Coptidis alkaloids extracted from Coptis chinensis Franch attenuate IFN-γ-induced destruction of bone marrow cells.PloS one · 2020Article
- Review
- Biphasic Dose-Response of Components FromDose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the underlying molecular mechanisms of Rhizoma coptidis are still far from being fully elucidated. Alkaloids, especially berberine, coptisine and palmatine, are responsible for multiple pharmacological effects of Rhizoma coptidis. In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.