ArticleFrontiers in immunology2018
Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Undifferentiated carcinomas in a large animal model of liver cancer.Animal models and experimental medicine · 2026Article
- Characterization of inflammatory pseudotumors in a large animal model of liver cancer.Animal models and experimental medicine · 2026Article
- Characterization of a bronchoscopically induced transgenic lung cancer pig model for human translatability.Lab animal · 2026Article
- Development of a high-grade glioma preclinical surgery model using an inducible KRAS/TP53 Oncopig.Frontiers in oncology · 2026Article
- Development of a genetically tailored implantation hepatocellular carcinoma model in Oncopigs by somatic cell CRISPR editing.Disease models & mechanisms · 2025Article
- Pigs: Large Animal Preclinical Cancer Models.World journal of oncology · 2024Review
- Benefits and opportunities of the transgenic Oncopig cancer model.Trends in cancer · 2024Article
- Swine global genomic resources: insights into wild and domesticated populations.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Induction and preliminary characterization of neoplastic pulmonary nodules in a transgenic pig model.Lung cancer (Amsterdam, Netherlands) · 2023Article
- Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig.Disease models & mechanisms · 2023Article
- The CRISPR/Cas9 Minipig-A Transgenic Minipig to Produce Specific Mutations in Designated Tissues.Cancers · 2021Article
- Transarterial Embolization of Liver Cancer in a Transgenic Pig Model.Journal of vascular and interventional radiology : JVIR · 2021Article
- Perspective: Humanized Pig Models of Bladder Cancer.Frontiers in molecular biosciences · 2021Article
- Genetically Engineered Pigs to Study Cancer.International journal of molecular sciences · 2020Review
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- Porcine Models of Pancreatic Cancer.Frontiers in oncology · 2019Review
- Induction and characterization of neoplastic bladder tumors in a transgenic porcine model.Bladder cancer (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In recent years, immunotherapy has shown considerable promise in the management of several malignancies. However, the majority of preclinical studies have been conducted in rodents, the results of which often translate poorly to patients given the substantial differences between murine and human immunology. As the porcine immune system is far more analogous to that of humans, pigs may serve as a supplementary preclinical model for future testing of such therapies. We have generated the genetically modified Oncopig with inducible tumor formation resulting from concomitant
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