ArticleScientific reports2018
A milk formula containing maltodextrin, vs. lactose, as main carbohydrate source, improves cognitive performance of piglets in a spatial task.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Carbohydrate composition of infant formula and glycemic regulation in early infancy using continuous glucose monitoring: cross-sectional evidence of altered glucose patterns with corn syrup solid-based formulas.The American journal of clinical nutrition · 2026Observational
- US infant formulas contain primarily added sugars: An analysis of infant formulas on the US market.Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems · 2025Article
- The Impact of Varying Lactose-to-Maltodextrin Ratios on the Physicochemical and Structural Characteristics of Pasteurized and Concentrated Skim and Whole Milk-Tea Blends.Foods (Basel, Switzerland) · 2024Article
- Altered Nutrient Composition of Lactose-Reduced Infant Formula.Nutrients · 2024Article
- Phenylalanine free infant formula in the dietary management of phenylketonuria.Orphanet journal of rare diseases · 2023Article
- Invited review: strategic adoption of antibiotic-free pork production: the importance of a holistic approach.Translational animal science · 2022Review
- Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management.Nutrients · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, lactose-free and low-lactose infant formulas have been increasingly used. The impact of using different carbohydrates than lactose on later cognition of formula-fed infants remains, however, unknown. We examined the effects of providing formulas containing either digestible maltodextrin or lactose as main carbohydrate source (28% of total nutrient composition) on cognitive performance of piglets. Piglets received the formulas from 1 to 9 weeks of age and, starting at 12 weeks, were individually tested in a spatial holeboard task (n = 8 pens/formula), in which they had to learn and memorize a configuration of baited buckets. After 28 acquisition trials, piglets were subjected to 16 reversal trials in which the location of the baited buckets was changed. Piglets fed the maltodextrin-based formula had higher reference memory (RM) scores than piglets fed the lactose-based formula towards the end of acquisition. During the switch of configuration, piglets offered the maltodextrin-based formula tended to have higher RM scores and make fewer RM errors than piglets offered the lactose-based formula. Working (short-term) memory was not affected by the formulas. Compared to lactose, the use of maltodextrin in milk formulas improved long-term spatial memory of piglets, even weeks after the end of the intervention.
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