ArticleScientific reports2018
Validation of biofilm formation on human skin wound models and demonstration of clinically translatable bacteria-specific volatile signatures.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Volatile Organic Compounds in the Early Diagnosis of Non-healing Surgical Wounds: A Systematic Review.World journal of surgery · 2022Pooled it
- Data-driven exploration of electronic nose technology to differentiate bacteria in blood cultures under biofilm-promoting conditions.Scientific reports · 2026Article
- Evolving Approaches to Bacterial Identification: A Review of Classical and Modern Techniques.International journal of molecular sciences · 2026Review
- Addressing infection in totally implantable venous access ports: An ex vivo study on bacterial transfer and the Forsvall Port needle design.The journal of vascular access · 2026Article
- Untargeted GC-IMS Metabolomics of Wound Headspace for Bacterial Infection Biomarker Discovery.Metabolites · 2026Article
- Infection-driven proliferative phase impairment in chronic wounds: a mechanistic framework for precision regenerative therapy.Frontiers in immunology · 2026Review
- Integration of localized microbiome, metabolome, and clinical datasets predicts healing in chronic wounds among veterans.bioRxiv : the preprint server for biology · 2025Article
- Volatile organic compounds (VOCs) detection for the identification of bacterial infections in clinical wound samples.Talanta · 2025Review
- Volatile organic compound detection of Buruli ulcer disease: Headspace analysis of Mycobacterium ulcerans and used gauzes of Buruli-compatible ulcers.PLoS neglected tropical diseases · 2024Article
- Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: Current state of the art.Journal of pharmaceutical analysis · 2024Review
- Volatilomes of human infection.Analytical and bioanalytical chemistry · 2024Review
- Article
- Why Do These Yeasts Smell So Good? Volatile Organic Compounds (VOCs) Produced byMolecules (Basel, Switzerland) · 2023Article
- [Levofloxacin combined with cellulase can eradicate bacille Calmette-Guerin biofilm infection].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Current Limitations of Staph Infection Diagnostics, and the Role for VOCs in Achieving Culture-Independent Detection.Pathogens (Basel, Switzerland) · 2023Review
- The biofilm life cycle: expanding the conceptual model of biofilm formation.Nature reviews. Microbiology · 2022Review
- The Human Skin Volatolome: A Systematic Review of Untargeted Mass Spectrometry Analysis.Metabolites · 2022Review
- A Combination of the Natural Molecules Gallic Acid and Carvacrol EradicatesInternational journal of molecular sciences · 2022Article
- Microrheology of Pseudomonas aeruginosa biofilms grown in wound beds.NPJ biofilms and microbiomes · 2022Article
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Biofilms are major contributors to delayed wound healing and there is a need for clinically relevant experimental models to assess theranostics. Microorganisms release volatile organic compounds (VOCs) and the ability to identify these in infected cutaneous wounds could lead to efficient non-invasive diagnosis. The aims here were to develop and assess bacterial biofilm formation and identify their VOC profiles in an in vitro model and validate in human ex vivo incisional and excisional cutaneous wound models. Biofilm development was assessed using multiple microscopy techniques with biofilm-forming deficient controls and quantified using metabolic and biomass assays; and VOC production measured by gas chromatography-mass spectrometry. The production of most VOCs was affected by biofilm development and model used. Some VOCs were specific either for planktonic or biofilm growth. The relative abundance of some VOCs was significantly increased or decreased by biofilm growth phase (P < 0.05). Some Staphylococcus aureus and Pseudomonas aeruginosa VOCs correlated with biofilm metabolic activity and biomass (R ≤ -0.5; ≥0.5). We present for the first time bacterial biofilm formation in human ex vivo cutaneous wound models and their specific VOC profiles. These models provide a vehicle for human skin-relevant biofilm studies and VOC detection has potential clinical translatability in efficient non-invasive diagnosis of wound infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.