ArticleScientific reports2018
Acetylcholine-modulated plasticity in reward-driven navigation: a computational study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Burst firing creates an attractor in synaptic weight dynamics.PLoS computational biology · 2026Article
- Cholinergic modulation enables scalable action selection learning in a computational model of the striatum.Scientific reports · 2025Article
- Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.Progress in neurobiology · 2025Article
- Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation.PLoS computational biology · 2025Article
- Brain-inspired learning rules for spiking neural network-based control: a tutorial.Biomedical engineering letters · 2025Review
- The precision principle: driving biological self-organization.Frontiers in network physiology · 2025Article
- Adverse event profile of memantine and donepezil combination therapy: a real-world pharmacovigilance analysis based on FDA adverse event reporting system (FAERS) data from 2004 to 2023.Frontiers in pharmacology · 2024Article
- Article
- Brain inspired path planning algorithms for drones.Frontiers in neurorobotics · 2023Article
- Meta-SpikePropamine: learning to learn with synaptic plasticity in spiking neural networks.Frontiers in neuroscience · 2023Article
- Dopamine and serotonin interplay for valence-based spatial learning.Cell reports · 2022Article
- The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning.PLoS computational biology · 2021Article
- Dopamine agonist treatment increases sensitivity to gamble outcomes in the hippocampus in de novo Parkinson's disease.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neuromodulation plays a fundamental role in the acquisition of new behaviours. In previous experimental work, we showed that acetylcholine biases hippocampal synaptic plasticity towards depression, and the subsequent application of dopamine can retroactively convert depression into potentiation. We also demonstrated that incorporating this sequentially neuromodulated Spike-Timing-Dependent Plasticity (STDP) rule in a network model of navigation yields effective learning of changing reward locations. Here, we employ computational modelling to further characterize the effects of cholinergic depression on behaviour. We find that acetylcholine, by allowing learning from negative outcomes, enhances exploration over the action space. We show that this results in a variety of effects, depending on the structure of the model, the environment and the task. Interestingly, sequentially neuromodulated STDP also yields flexible learning, surpassing the performance of other reward-modulated plasticity rules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.