ArticleScientific reports2018
Immune interconnectivity of anatomically distant tumors as a potential mediator of systemic responses to local therapy.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
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- Evolutionary Double-Bind Treatment Using Radiation Therapy and Natural Killer Cell-Based Immunotherapy in Prostate Cancer.International journal of radiation oncology, biology, physics · 2026Article
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- Mathematical modeling in radiotherapy for cancer: a comprehensive narrative review.Radiation oncology (London, England) · 2025Review
- Spatially fractionated GRID radiation potentiates immune-mediated tumor control.Radiation oncology (London, England) · 2024Article
- Investigating Radiotherapy Effects on PD-L1 Expression in Circulating Tumor Cells: An Exploratory Study.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Modeling the Synergistic Impact of Yttrium 90 Radioembolization and Immune Checkpoint Inhibitors on Hepatocellular Carcinoma.Bioengineering (Basel, Switzerland) · 2024Article
- Radiation combined with ultrasound and microbubbles: A potential novel strategy for cancer treatment.Zeitschrift fur medizinische Physik · 2023Review
- Article
- Analysis of cellular kinetic models suggest that physiologically based model parameters may be inherently, practically unidentifiable.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system.Neoplasia (New York, N.Y.) · 2022Review
- Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma.Journal of experimental & clinical cancer research : CR · 2022Article
- Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy.Cellular & molecular immunology · 2022Review
- Circulating immune cell populations related to primary breast cancer, surgical removal, and radiotherapy revealed by flow cytometry analysis.Breast cancer research : BCR · 2021Article
- Metastatic feline mammary cancer: prognostic factors, outcome and comparison of different treatment modalities - a retrospective multicentre study.Journal of feline medicine and surgery · 2021Article
- Quantifying the limits of CAR T-cell delivery in mice and men.Journal of the Royal Society, Interface · 2021Article
- A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020Article
- Implications of immune-mediated metastatic growth on metastatic dormancy, blow-up, early detection, and treatment.Journal of mathematical biology · 2020Article
- Primary and metastatic breast tumors cross-talk to influence immunotherapy responses.Oncoimmunology · 2020Article
- Telomerase and CD4 T Cell Immunity in Cancer.Cancers · 2020Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Complex interactions occur between tumor and host immune system at each site in the metastatic setting, the outcome of which can determine behavior ranging from dormancy to rapid growth. An additional layer of complexity arises from the understanding that cytotoxic T cells can traffic through the host circulatory system. Coupling mathematical models of local tumor-immune dynamics and systemic T cell trafficking allows us to simulate the evolution of tumor and immune cell populations in anatomically distant sites following local therapy and thus computationally evaluate immune interconnectivity. Results suggest that the presence of a secondary site may either inhibit or promote growth of the primary, depending on the capacity for immune recruitment of each tumor and the resulting systemic redistribution of T cells. Treatment such as surgical resection and radiotherapy can be simulated to estimate both the decrease in tumor volume at the local treatment-targeted site, and the change in overall tumor burden and tumor growth trajectories across all sites. Qualitatively similar responses of distant tumors to local therapy (positive and negative abscopal effects) to those reported in the clinical setting were observed. Such findings may facilitate an improved understanding of general disease kinetics in the metastatic setting: if metastatic sites are interconnected through the immune system, truly local therapy does not exist.
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