ArticleNature chemistry2018
Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals.
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Ligand-Enabled Stereoselective Coupling of Methylene C(spAngewandte Chemie (International ed. in English) · 2026Article
- Ru(II)-Catalyzed C-H Sulfonamidation of the Medicinally Relevant Benzodiazepine Scaffolds.Organic letters · 2026Article
- Arene Ruthenium(II) Carboxylates for C─H Alkylations and Arylations at Near Room Temperature.Angewandte Chemie (International ed. in English) · 2025Article
- The Mechanism of Ruthenium-Catalyzed Directed C─H Arylation of Arenes: The Key Role of Bis-Cyclometalated Intermediates.Angewandte Chemie (International ed. in English) · 2025Article
- Bis-Cycloruthenated Complexes in Visible Light-Induced C-H Alkylation with Epoxides.Journal of the American Chemical Society · 2025Article
- Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(Nature catalysis · 2025Article
- Repurposing a supramolecular iridium catalystChemical science · 2024Article
- An air- and moisture-stable ruthenium precatalyst for diverse reactivity.Nature chemistry · 2024Article
- Unlocking regioselective meta-alkylation with epoxides and oxetanes via dynamic kinetic catalyst control.Nature communications · 2024Article
- Electrochemical Late-Stage Functionalization.Chemical reviews · 2023Review
- Transition-Metal-Catalyzed C-H Bond Activation for the Formation of C-C Bonds in Complex Molecules.Chemical reviews · 2023Review
- Improving the sustainability of the ruthenium-catalysedGreen chemistry : an international journal and green chemistry resource : GC · 2023Article
- Article
- Ruthenium-Catalyzed Monoselective C-H Methylation andJACS Au · 2022Article
- Ru(II)-Catalyzed Hydroarylation of in situ Generated 3,3,3-Trifluoro-1-propyne by C-H Bond Activation: A Facile and Practical Access to β-Trifluoromethylstyrenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Identification of α-Synuclein Proaggregator: Rapid Synthesis and Streamlining RT-QuIC Assays in Parkinson's Disease.ACS medicinal chemistry letters · 2022Article
- Photo-Induced Ruthenium-Catalyzed Double Remote C(spAngewandte Chemie (International ed. in English) · 2022Article
- Pd(ii)-catalyzedChemical science · 2022Article
- Expanding chemical space by para-C-H arylation of arenes.Nature communications · 2022Article
- Ruthenaelectro-catalyzed C-H acyloxylation for late-stage tyrosine and oligopeptide diversification.Chemical science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biaryls are ubiquitous core structures in drugs, agrochemicals and organic materials that have profoundly improved many aspects of our society. Although traditional cross-couplings have made practical the synthesis of many biaryls, C-H arylation represents a more attractive and cost-effective strategy for building these structural motifs. Furthermore, the ability to install biaryl units in complex molecules via late-stage C-H arylation would allow access to valuable structural diversity, novel chemical space and intellectual property in only one step. However, known C-H arylation protocols are not suitable for substrates decorated with polar and delicate functionalities, which are commonly found in molecules that possess biological activity. Here we introduce a class of ruthenium catalysts that display a unique efficacy towards late-stage arylation of heavily functionalized substrates. The design and development of this class of catalysts was enabled by a mechanistic breakthrough on the Ru(II)-catalysed C-H arylation of N-chelating substrates with aryl (pseudo)halides, which has remained poorly understood for nearly two decades.
Indexed as
Identifiers
29930274What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.