ArticleScientific reports2018
Genetic and chemical differentiation characterizes top-geoherb and non-top-geoherb areas in the TCM herb rhubarb.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Article
- Dissecting alternative splicing patterns of the Rheum palmatum complex with different contents of medicinal constituents.BMC genomics · 2025Article
- Article
- Incorporating Genetic Diversity to Optimize the Plant Conservation Network in the Third Pole.Global change biology · 2025Article
- Article
- Comparative transcriptome analysis and HPLC reveal candidate genes associated with synthesis of bioactive constituents inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- A chromosome-level genome reveals genome evolution and molecular basis of anthraquinone biosynthesis in Rheum palmatum.BMC plant biology · 2024Article
- Transcriptomic divergence of the Rheum palmatum complex derived from top-geoherb and non-geoherb areas provides the insights into geoherbalism properties of rhubarb.BMC genomics · 2024Article
- Phylogeographic analysis ofEcology and evolution · 2023Article
- Phylogenomics, phylogeography and germplasms authentication of the Rheum palmatum complex based on complete chloroplast genomes.Journal of plant research · 2023Article
- Transcriptome profiles of yellowish-white and fuchsia colored flowers in the Rheum palmatum complex reveal genes related to color polymorphism.Plant molecular biology · 2022Article
- Tissue-specific transcriptome forPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Non-target metabolomics revealed the differences between Rh. tanguticum plants growing under canopy and open habitats.BMC plant biology · 2021Article
- Label-Free Proteomic Analysis of Smoke-Drying and Shade-Drying Processes of Postharvest Rhubarb: A Comparative Study.Frontiers in plant science · 2021Article
- Complete chloroplast genome sequence determination of Rheum species and comparative chloroplast genomics for the members of Rumiceae.Plant cell reports · 2020Article
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11 authors.
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Abstract
Medicinal herbs of high quality and with significant clinical effects have been designated as top-geoherbs in traditional Chinese medicine (TCM). However, the validity of this concept using genetic markers has not been widely tested. In this study, we investigated the genetic variation within the Rheum palmatum complex (rhubarb), an important herbal remedy in TCM, using a phylogeographic (six chloroplast DNA regions, five nuclear DNA regions, and 14 nuclear microsatellite loci) and a chemical approach (anthraquinone content). Genetic and chemical data identified two distinct groups in the 38 analysed populations from the R. palmatum complex which geographically coincide with the traditional top-geoherb and non-top-geoherb areas of rhubarb. Molecular dating suggests that the two groups diverged in the Quaternary c. 2.0 million years ago, a time of repeated climate changes and uplift of the Qinghai-Tibetan Plateau. Our results show that the ancient TCM concept of top-geoherb and non-top-geoherb areas corresponds to genetically and chemically differentiated groups in rhubarb.
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