Evidence map›Paper›PMID 29930241›Full record

ArticleAnnals of transplantation2018

T Cell-Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation for Treatment of T-Lymphoblastic Lymphoma.

Lixun Guan, Xiaohong Li, Huaping Wei, Zhenyang Gu, Shasha Zhao, Chengying Zhu, Nan Yang, Feiyan Wang, Lan Luo, Zhe Gao and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Annals of transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Graft CD8International journal of hematology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Lymphoblastic Lymphoma: a Concise Review.Current oncology reports · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Lixun GuanDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Xiaohong LiDepartment of Hematology, First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
Huaping WeiDepartment of Hematology and Oncology, Beijing Huairou Hospital, Beijing, China (mainland).
Zhenyang GuDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Shasha ZhaoDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Chengying ZhuDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Nan YangDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Feiyan WangDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Lan LuoDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Zhe GaoDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Wenrong HuangDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Honghua LiDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Quanshun WangDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Daihong LiuDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Xiaoxiong WuDepartment of Hematology, First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland).
Chunji GaoDepartment of Hematology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).
Chinese People's Liberation Army · CNFirst Affiliated Hospital of Chinese PLA General Hospital · CNBeijing Chuiyangliu Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND There is currently little information on haploidentical hematopoietic cell transplantation (haplo-HCT) for T-lymphoblastic lymphoma (T-LBL). Data about peripheral blood stem cells (PBSC) as a reliable graft source for T-LBL treatment are lacking. MATERIAL AND METHODS T-LBL patients who underwent T cell-replete haploidentical peripheral blood hematopoietic cell transplantation (haplo-PBHCT) from July 2007 to January 2017 were retrospectively evaluated. RESULTS A total of 25 patients (age ≥15 years) with median age of 24 (range 15-51) years were enrolled. The median number of CD34+ cells infused was 5.0 (1.6-14.4) 106/kg. Sustained myeloid engraftment with full donor chimerism was achieved in all patients. The cumulative incidence of grades 2 to 4 acute graft-versus-host disease (GVHD) at day 100 was 24%. Two-year extensive chronic GVHD cumulative incidence was 20%. The 3-year overall survival rate for all patients was 70%. The median survival time of the complete remission (CR) group was better than that of the non-CR group (not reached vs. 9 m) (P<0.01). The relapse rate was 17% for patients who obtained CR and were given haplo-HCT as consolidation treatment. CONCLUSIONS This study indicates that haplo-PBHCT is a safe and effective method for the treatment of T-LBL.

Indexed as

AdolescentAdultFemaleHistocompatibility TestingHumansMaleMiddle AgedPeripheral Blood Stem Cell TransplantationPrecursor Cell Lymphoblastic Leukemia-LymphomaRetrospective StudiesT-LymphocytesTransplantation ConditioningTreatment OutcomeYoung Adult

Identifiers

PMID29930241
PMCPMC6248294
OpenAlexW2809164184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.