Evidence map›Paper›PMID 29930162›Full record

ArticleHaematologica2018

A reversible carnitine palmitoyltransferase (CPT1) inhibitor offsets the proliferation of chronic lymphocytic leukemia cells.

Elena Gugiatti, Claudya Tenca, Silvia Ravera, Marina Fabbi, Fabio Ghiotto, Andrea N Mazzarello, Davide Bagnara, Daniele Reverberi, Daniela Zarcone, Giovanna Cutrona and 5 more

Abstract readLetter
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. The emerging metabolic role and treatment target of CPT1A in CRC.Frontiers in cell and developmental biology · 2026
    Review
  3. Review
  4. Review
  5. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  6. Carnitine Shuttle and Ferroptosis in Cancer.Antioxidants (Basel, Switzerland) · 2025
    Review
  7. Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025
    Review
  8. Article
  9. Lipid metabolism in B cell biology.Molecular oncology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. The role of liver kinase B1 in tumor progression through regulation of lipid metabolism.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  17. Targeting Energy Metabolism in Cancer Treatment.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elena GugiattiDepartment of Experimental Medicine, University of Genoa, Italy.
Claudya TencaDepartment of Experimental Medicine, University of Genoa, Italy.
Silvia RaveraDepartment of Pharmacy, University of Genoa, Italy.
Marina FabbiBiotherapies Unit, Ospedale Policlinico San Martino, Genoa, Italy.
Fabio GhiottoDepartment of Experimental Medicine, University of Genoa, Italy.
Andrea N MazzarelloThe Feinstein Institute for Medical Research, North Shore-Long Island, Experimental Immunology, Manhasset, NY, USA.
Davide BagnaraDepartment of Experimental Medicine, University of Genoa, Italy.
Daniele ReverberiMolecular Pathology Unit, Ospedale Policlinico San Martino, Genoa, Italy.
Daniela ZarconeDepartment of Experimental Medicine, University of Genoa, Italy.
Giovanna CutronaMolecular Pathology Unit, Ospedale Policlinico San Martino, Genoa, Italy.
Adalberto IbaticiHematology Unit and Bone Marrow Transplantation, Ospedale Policlinico San Martino, Genoa, Italy.
Ermanno CicconeDepartment of Experimental Medicine, University of Genoa, Italy.
Zbigniew DarzynkiewiczBrander Cancer Research Institute, Department of Pathology, New York Medical College, NY, USA.
Franco FaisDepartment of Experimental Medicine, University of Genoa, Italy.
Silvia BrunoDepartment of Experimental Medicine, University of Genoa, Italy silvia.bruno@unige.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellA549 CellsCarnitine O-PalmitoyltransferaseCell ProliferationEnzyme InhibitorsHCT116 CellsHumansMCF-7 CellsNeoplasm ProteinsPC-3 CellsCarnitine O-PalmitoyltransferaseEnzyme InhibitorsNeoplasm Proteins

Identifiers

PMID29930162
PMCPMC6278982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.