ArticleBlood2018
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04889729 (Genomic and Personalized Medicine for All), which is not on this map. Cited by 153 papers.
0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genomic and Personalized Medicine for All (GENOMED4ALL): Application of Artificial Intelligence to Improve Disease Classification and Prognosis in Myelodysplastic Syndrome.
Who cites it
153 citing papers in PubMed, 242 citations in OpenAlex.
- Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia.Leukemia · 2020Trial
- A variant erythroferrone disrupts iron homeostasis inScience translational medicine · 2019Trial
- Article
- Nonsense-Mediated RNA Decay Is a Targetable Vulnerability in Splicing Factor Mutant Myeloid Neoplasms by Enhancing R-Loop Accumulation and DNA Damage.Cancer research · 2026Article
- An Immune Dysfunction Signature Score Predicts Survival in MDS Patients: Insights From a Longitudinal, Multicenter Study.Cancer science · 2026Article
- Splicing-driven post-translational dysregulation: a new frontier for precision cancer medicine and immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- U2af1Leukemia · 2026Article
- Tumoral switch in NUMB splicing changes essential transcription pathways and induces malignant properties in tumour cells.Genome biology · 2026Article
- Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy.Cells · 2026Review
- Variant-specific SF3B1 mutations drive distinct splicing and mitochondrial dysfunction in myelodysplastic neoplasms.Human genomics · 2026Article
- NAT10 maintains stem cell homeostasis by mitigating mRNA decay through an acNature cell biology · 2026Article
- Noncanonical Transcription and Splicing Shape the Colorectal Cancer Immunopeptidome in MSI and MSS Tumors.Molecular & cellular proteomics : MCP · 2026Article
- Real-world, multi-omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS).HemaSphere · 2026Article
- Article
- Chromatin rewiring of β-globin and MYC enhancers by TGF-β1 drives defective erythropoiesis.Nature communications · 2026Article
- Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation.Science advances · 2026Article
- Mutant SRSF2-associated impaired erythropoiesis is defined by increased mTORC1 signaling due to FYN missplicing.Leukemia · 2026Article
- Systematic and Quantitative Investigation of Newly Synthesized Proteins Reveals Distinct Ion Homeostasis and Mitochondrial Changes between Cuproptosis and Ferroptosis in Human Cells.Analytical chemistry · 2026Article
- Exploring exosome-related genes as candidate biomarkers in primary immune thrombocytopenia through transcriptomics and preliminary experimental validation.Scientific reports · 2026Article
- Transcriptional readthrough precedes alternative splicing programs triggered in CML cells by imatinib.Science advances · 2026Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
30 authors at 11 institutions in 5 countries.
Andrea PellagattiNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6122-0221
Richard N ArmstrongNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7744-5890
Violetta SteeplesNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Eshita SharmaWellcome Trust Centre for Human Genetics and.
Emmanouela RepapiThe Computational Biology Research Group, Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, United Kingdom.
Shalini SinghNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Andrea SanchiNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Aleksandar RadujkovicDepartment of Internal Medicine V, University Hospital Heidelberg, Germany.
Patrick HornDepartment of Internal Medicine V, University Hospital Heidelberg, Germany.
Hamid DolatshadNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Swagata RoyNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
John BroxholmeWellcome Trust Centre for Human Genetics and.
Helen LockstoneWellcome Trust Centre for Human Genetics and.
Stephen TaylorThe Computational Biology Research Group, Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, United Kingdom.
Aristoteles GiagounidisClinic for Oncology, Hematology, and Palliative Medicine, Marien Hospital Düsseldorf, Germany.
Paresh VyasMedical Research Council Molecular Hematology Unit, WIMM, University of Oxford, United Kingdom.
Anna SchuhMolecular Diagnostics Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Angela HamblinMolecular Diagnostics Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Elli PapaemmanuilDepartment of Epidemiology-Biostatistics, Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY.
Sally KillickDepartment of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom.
Luca MalcovatiDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Marco L HennrichEuropean Molecular Biology Laboratory Structural and Computational Biology Unit, Heidelberg, Germany.
Anne-Claude GavinEuropean Molecular Biology Laboratory Structural and Computational Biology Unit, Heidelberg, Germany.
Anthony D HoDepartment of Internal Medicine V, University Hospital Heidelberg, Germany.
Thomas LuftDepartment of Internal Medicine V, University Hospital Heidelberg, Germany.
Eva Hellström-LindbergCenter for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, Sweden; and.
Mario CazzolaDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Christopher W J SmithDepartment of Biochemistry and.
Stephen SmithDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Jacqueline BoultwoodNuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4330-2928
University of Oxford · GBHeidelberg University · DECentre for Human Genetics · GBEuropean Molecular Biology Laboratory · DEOxford University Hospitals NHS Trust · GBUniversity of Pavia · ITKarolinska University Hospital · SEMarien Hospital Düsseldorf · DEMemorial Sloan Kettering Cancer Center · USRoyal Bournemouth Hospital · GBUniversity of Cambridge · GB
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MMedical Research Council G1000729Medical Research Council MC_U137961146Medical Research Council MC_UU_00016/11Medical Research Council MC_UU_12009/11Medical Research Council MR/L008963/1Medical Research Council MR/R001146/1NCI NIH HHS P30 CA008748
Abstract
PubMed holds no abstract for this paper.
Indexed as
MutationRNA SplicingCohort StudiesDNA RepairGene Expression RegulationHumansMyelodysplastic SyndromesPhosphoproteinsRNA Splicing FactorsSerine-Arginine Splicing FactorsSpliceosomesSplicing Factor U2AFSurvival AnalysisPhosphoproteinsRNA Splicing FactorsSerine-Arginine Splicing FactorsSF3B1 protein, humanSplicing Factor U2AFSRSF2 protein, humanU2AF1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04889729ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.