Evidence map›Paper›PMID 29929992›Full record

ArticleJournal of the American Heart Association2018

Size Matters: Ryanodine Receptor Cluster Size Affects Arrhythmogenic Sarcoplasmic Reticulum Calcium Release.

Samuel Galice, Yuanfang Xie, Yi Yang, Daisuke Sato, Donald M Bers

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Structural Integrity of RyR2 Clusters Controls Cardiac Calcium Leak.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Mechanisms of spontaneous CaThe Journal of physiology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samuel GaliceDepartment of Pharmacology, University of California Davis, Davis, CA.
Yuanfang XieDepartment of Pharmacology, University of California Davis, Davis, CA.
Yi YangDepartment of Pharmacology, University of California Davis, Davis, CA.
Daisuke SatoDepartment of Pharmacology, University of California Davis, Davis, CA.
Donald M BersDepartment of Pharmacology, University of California Davis, Davis, CA dmbers@ucdavis.edu.
University of California, Davis · US

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR37HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2005 to 2014
$3.9M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
Multi-scale Systems Model of Murine Heart FailureR01HL105242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BERS, DONALD M, MCCULLOCH, ANDREW D. · 2012 to 2016
$3.5M
High-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure TherapyR01HL138539 · NHLBI · UNIVERSITY OF MINNESOTA · PI BERS, DONALD M, CORNEA, RAZVAN LIVIU · 2018 to 2021
$3.1M
AKAP-dependent regulation of Cardiac SR Ca handlingR01HL133832 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2017 to 2020
$2.0M
Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced ArrhythmiasR00HL111334 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SATO, DAISUKE · 2015 to 2017
$738k
Modeling of Cardiac Calcium Dynamics; Ryanodine Receptor induced ArrhythmiasK99HL111334 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SATO, DAISUKE · 2012 to 2013
$194k
NHLBI NIH HHS K99 HL111334NHLBI NIH HHS R00 HL111334NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL105242NHLBI NIH HHS R01 HL133832NHLBI NIH HHS R01 HL138539NHLBI NIH HHS R37 HL030077
6 · The paper itself

Abstract

backgroundRyanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca METHODS AND

resultsHere we measured RyR cluster size and Ca

conclusionsOur study explains how this combination of properties may limit arrhythmogenic Ca

Indexed as

Calcium SignalingHeart RateAction PotentialsAnimalsArrhythmias, CardiacComputer SimulationExcitation Contraction CouplingHumansIon Channel GatingModels, CardiovascularMyocytes, CardiacRats, Sprague-DawleyRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumTacrolimus Binding ProteinsFKBP1A protein, humanRyanodine Receptor Calcium Release ChannelTacrolimus Binding Proteinscalcium regulationcalcium signalingcalcium sparksryanodine receptor

Identifiers

PMID29929992
PMCPMC6064922
OpenAlexW2809239518

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.