ArticleJournal of the American Heart Association2018
Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community-Based Cohort.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Retinol-binding Protein 4 as a Predictor of Cardiovascular Events after Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction.Journal of atherosclerosis and thrombosis · 2026Article
- Article
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Prognostic Value of Modified Glasgow Prognostic Score in Acute Decompensated Heart Failure with Reduced Ejection Fraction.Journal of clinical practice and research · 2025Article
- Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis.ESC heart failure · 2025Article
- Early menopause is associated with abnormal diastolic function and poor clinical outcomes in women with suspected angina.Scientific reports · 2024Article
- The Role of Adipokines in Health and Disease.Biomedicines · 2023Review
- Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases.Frontiers in physiology · 2022Review
- Prospective association of serum adipocyte fatty acid-binding protein with heart failure hospitalization in diabetes.ESC heart failure · 2021Article
- Bariatric Surgery and Hypertension.Journal of clinical medicine · 2021Review
- Possible diverse contribution of coronary risk factors to left ventricular systolic and diastolic cavity sizes.Scientific reports · 2021Article
- Angiopoietin-Like Protein 8/Leptin Crosstalk Influences Cardiac Mass in Youths With Cardiometabolic Risk: The BCAMS Study.Frontiers in endocrinology · 2021Article
- Association between adipocyte fatty acid-binding protein with left ventricular remodelling and diastolic function in type 2 diabetes: a prospective echocardiography study.Cardiovascular diabetology · 2020Article
- The adipokine fatty-acid binding protein 4 and cardiac remodeling.Cardiovascular diabetology · 2020Article
- The effect of leptin on blood pressure considering smoking status: a Mendelian randomization study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community-Based Cohort.Journal of the American Heart Association · 2018Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAdipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity-associated heart failure remains uncertain. We investigated the associations between circulating adipokine concentrations and echocardiographic measures in a community-based sample. METHODS AND
resultsWe evaluated 3514 Framingham Heart Study participants (mean age 40 years, 53.8% women) who underwent routine echocardiography and had select circulating adipokines measured, ie, leptin, soluble leptin receptor, fatty acid-binding protein 4, retinol-binding protein 4, fetuin-A, and adiponectin. We used multivariable linear regression, adjusting for known correlates (including weight), to relate adipokine concentrations (independent variables) to the following echocardiographic measures (dependent variables): left ventricular mass index, left atrial diameter in end systole, fractional shortening, and E/e'. In multivariable-adjusted analysis, left ventricular mass index was inversely related to circulating leptin and fatty acid-binding protein 4 concentrations but positively related to retinol-binding protein 4 and leptin receptor levels (
conclusionsIn our cross-sectional study of a large, young to middle-aged, relatively healthy community-based sample, key indices of subclinical cardiac remodeling were associated with higher or lower circulating concentrations of prohypertrophic and antihypertrophic adipokines in a context-specific manner. These observations may offer insights into the pathogenesis of the cardiomyopathy of obesity.
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