ArticleThe Journal of endocrinology2018
Sex-specific changes in postnatal GH and PRL secretion in somatotrope LEPR-null mice.
Article in The Journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice.Endocrinology · 2025Article
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes.Frontiers in endocrinology · 2025Article
- Characterization and Regulation of the Neonatal Growth Hormone Surge.Endocrinology · 2024Article
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain.Frontiers in endocrinology · 2023Article
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.Endocrinology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The developing pituitary is a rapidly changing environment that is constantly meeting the physiological demands of the growing organism. During early postnatal development, the anterior pituitary is refining patterns of anterior hormone secretion in response to numerous genetic factors. Our laboratory previously developed a somatotrope leptin receptor (LEPR) deletion mouse model that had decreased lean body mass, disrupted metabolism, decreased GH stores and was GH deficient as an adult. To understand how deletion of LEPR in somatotropes altered GH, we turned our attention to postnatal development. The current study examines GH, PRL, TSH, ACTH, LH and FSH secretion during postnatal days 4, 5, 8, 10 and 15 and compares age and sex differences. The LEPR mutants have dysregulation of GH (
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