Evidence map›Paper›PMID 29929985›Full record

ArticleThe Journal of biological chemistry2018

Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking.

Eunice C Chan, Chunguang Ren, Zhihui Xie, Joseph Jude, Tolga Barker, Cynthia A Koziol-White, Michelle Ma, Reynold A Panettieri, Dianqing Wu, Helene F Rosenberg and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  12. Unrestrained GαFrontiers in immunology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Eunice C ChanMolecular Signal Transduction Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
Chunguang RenDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.
Zhihui XieMolecular Signal Transduction Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
Joseph JudeRutgers Institute for Translational Medicine and Science, Child Health Institute of New Jersey, Rutgers New Jersey School of Medicine, Rutgers, New Jersey 07103.
Tolga BarkerMolecular Signal Transduction Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
Cynthia A Koziol-WhiteRutgers Institute for Translational Medicine and Science, Child Health Institute of New Jersey, Rutgers New Jersey School of Medicine, Rutgers, New Jersey 07103.
Michelle MaInflammation Immunobiology Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
Reynold A PanettieriRutgers Institute for Translational Medicine and Science, Child Health Institute of New Jersey, Rutgers New Jersey School of Medicine, Rutgers, New Jersey 07103.
Dianqing WuDepartment of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.
Helene F RosenbergInflammation Immunobiology Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
Kirk M DrueyMolecular Signal Transduction Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892. Electronic address: kdruey@niaid.nih.gov.
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USRutgers, The State University of New Jersey · USYale University · US

Funding

Inflammation and Therapy for Respiratory Virus InfectionZIAAI000943 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSENBERG, HELENE · 2009 to 2020
$7.4M
Heterotrimeric G Protein Signaling In Allergic InflammationZIAAI000746 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DRUEY, KIRK M · 2009 to 2025
$4.6M
HETEROTRIMERIC G PROTEIN SIGNALING IN ALLERGIC INFLAMMATIONZ01AI000746 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI DRUEY, KIRK M · 1998 to 2008
$1.1M
Intramural NIH HHS Z01 AI000746
6 · The paper itself

Abstract

Neutrophils are white blood cells that are mobilized to damaged tissues and to sites of pathogen invasion, providing the first line of host defense. Chemokines displayed on the surface of blood vessels promote migration of neutrophils to these sites, and tissue- and pathogen-derived chemoattractant signals, including

Indexed as

ChemotaxisAnimalsCell AdhesionCell MovementCells, CulturedChemotactic FactorsHumansMiceMice, Inbred BALB CMice, KnockoutNeutrophilsN-Formylmethionine Leucyl-PhenylalanineRGS ProteinsSignal TransductionChemotactic FactorsN-Formylmethionine Leucyl-PhenylalanineRGS5 protein, humanRgs5 protein, mouseRGS ProteinschemotaxisGPCRG protein–coupled receptorinflammationinnate immunityleukocyteneutrophilregulator of G protein signalingRGStrafficking

Identifiers

PMID29929985
PMCPMC6102127
OpenAlexW2987090693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.