ArticlePsychosomatics
Delirium's Arousal Subtypes and Their Relationship with 6-Month Functional Status and Cognition.
Article in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment and report of individual symptoms in studies of delirium in postoperative populations: a systematic review.Age and ageing · 2024Pooled it
- Delirium Severity Trajectories and Outcomes in ICU Patients. Defining a Dynamic Symptom Phenotype.Annals of the American Thoracic Society · 2020Trial
- [Incidence and factors associated with delirium in an Emergency Department].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
- Factors Influencing Engagement with in-Person Intensive Care Unit Recovery Clinic Services.Journal of intensive care medicine · 2023Article
- Association of Pain During the Evaluation of Delirium in Intensive Care Unit Patients.Frontiers in medicine · 2021Article
- Delirium Prevention, Detection, and Treatment in Emergency Medicine Settings: A Geriatric Emergency Care Applied Research (GEAR) Network Scoping Review and Consensus Statement.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice.Current neuropharmacology · 2021Review
- Delirium and Associated Factors in a Cohort of Hospitalized Patients With Coronavirus Disease 2019.Journal of the Academy of Consultation-Liaison PsychiatryArticle
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Authors and funding
9 authors.
Funding
Abstract
objectiveWe sought to determine how delirium subtyped by arousal affected 6-month function and cognition in acutely ill older patients.
methodsThis was secondary analysis of a prospective cohort study which enrolled hospitalized patients ≥65 years old. Delirium and arousal were ascertained daily in the emergency department and the first 7 days of hospitalization using the modified Brief Confusion Assessment Method and Richmond Agitation Sedation Scale, respectively. For each day, patients were categorized as having no delirium, delirium with normal arousal, delirium with decreased arousal, or delirium with increased arousal. Preillness and 6-month functional status were determined using the Older American Resources and Services activities of daily living scale which ranges from 0 (completely dependent) to 28 (completely independent). Preillness and 6-month cognition were determined using the Informant Questionnaire on Cognitive Decline in the Elderly which ranges from 1 (markedly improved cognition) to 5 (severe cognitive impairment). Multiple linear regression was performed adjusted for preillness Older American Resources and Services activities of daily living and Informant Questionnaire on Cognitive Decline in the Elderly and other relevant confounders.
resultsIn 228 older patients, delirium with normal arousal was the only subtype independently associated with poorer 6-month function and cognition. For every day spent in this subtype, the 6-month Older American Resources and Services activities of daily living decreased by 0.84 points (95% confidence interval: -1.59 to -0.09) and the patient's 6-month Informant Questionnaire on Cognitive Decline in the Elderly significantly increased by 0.14 points (95% confidence interval: 0.06-0.23).
conclusionsDelirium with normal arousal, as opposed to delirium with decreased or increased arousal, was the only arousal subtype significantly associated with worsening 6-month function and cognition. Subtyping delirium by arousal may have important prognostic value.
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