Evidence map›Paper›PMID 29929523›Full record

ArticleBMC health services research2018

A novel design process for selection of attributes for inclusion in discrete choice experiments: case study exploring variation in clinical decision-making about thrombolysis in the treatment of acute ischaemic stroke.

Aoife De Brún, Darren Flynn, Laura Ternent, Christopher I Price, Helen Rodgers, Gary A Ford, Matthew Rudd, Emily Lancsar, Stephen Simpson, John Teah and 1 more

Abstract read
In one paragraph

Article in BMC health services research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Cancer survivor preferences for breast cancer follow-up care: a discrete choice experiment.Journal of cancer survivorship : research and practice · 2026
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  8. Task Shifting, eHealth and Shared Decision-Making-Preference Heterogeneity in the Adult Population for Developments in Outpatient Primary Healthcare.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Examining patient and professional perspectives in the UK for gene therapy in haemophilia.Haemophilia : the official journal of the World Federation of Hemophilia · 2022
    Article
  17. Review
  18. Article
  19. Patient perspectives regarding gene therapy in haemophilia: Interviews from the PAVING study.Haemophilia : the official journal of the World Federation of Hemophilia · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aoife De BrúnInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK. aoife.debrun@ucd.ie.ORCID 0000-0003-0124-0893
Darren FlynnInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Laura TernentInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Christopher I PriceNIHR Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Trust and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Helen RodgersStroke Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Gary A FordStroke Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Matthew RuddStroke Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Emily LancsarDepartment of Health Services Research and Policy, Research School of Population Health, Australian National University, Canberra, Australia.
Stephen SimpsonThe Stroke Association, Gateshead, UK.
John TeahThe Stroke Association, Gateshead, UK.
Richard G ThomsonInstitute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Funding

Department of Health 12/5001/45Department of Health RP-PG-1211-20012Health Services and Delivery Research Programme 12/5001/45
6 · The paper itself

Abstract

backgroundA discrete choice experiment (DCE) is a method used to elicit participants' preferences and the relative importance of different attributes and levels within a decision-making process. DCEs have become popular in healthcare; however, approaches to identify the attributes/levels influencing a decision of interest and to selection methods for their inclusion in a DCE are under-reported. Our objectives were: to explore the development process used to select/present attributes/levels from the identified range that may be influential; to describe a systematic and rigorous development process for design of a DCE in the context of thrombolytic therapy for acute stroke; and, to discuss the advantages of our five-stage approach to enhance current guidance for developing DCEs.

methodsA five-stage DCE development process was undertaken. Methods employed included literature review, qualitative analysis of interview and ethnographic data, expert panel discussions, a quantitative structured prioritisation (ranking) exercise and pilot testing of the DCE using a 'think aloud' approach.

resultsThe five-stage process reported helped to reduce the list of 22 initial patient-related factors to a final set of nine variable factors and six fixed factors for inclusion in a testable DCE using a vignette model of presentation.

conclusionsIn order for the data and conclusions generated by DCEs to be deemed valid, it is crucial that the methods of design and development are documented and reported. This paper has detailed a rigorous and systematic approach to DCE development which may be useful to researchers seeking to establish methods for reducing and prioritising attributes for inclusion in future DCEs.

Indexed as

Thrombolytic TherapyChoice BehaviorClinical Decision-MakingExerciseHumansIschemiaMalePatient PreferenceQualitative ResearchStrokeAcute ischaemic strokeClinical decision-makingDesign processDiscrete choice experimentIntravenous thrombolysisMethodologyPatient vignettes

Identifiers

PMID29929523
PMCPMC6013945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.