ArticleBMC ophthalmology2018
The association between glaucoma and risk of depression: a nationwide population-based cohort study.
Article in BMC ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Assessment of the relationship between living alone and the risk of depression based on longitudinal studies: A systematic review and meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Mental health assessment in glaucoma patients: Evidence from a tertiary care center in North India.Indian journal of ophthalmology · 2026Article
- Associations of anxiety disorders, physical activity and open-angle glaucoma: a population-based analysis.Scientific reports · 2026Article
- Independent associations of physical activity and depression with open-angle glaucoma in a population-based analysis.Scientific reports · 2025Article
- Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank.Translational vision science & technology · 2025Article
- Nonarteritic anterior ischemic optic neuropathy and the incidence of depression: a nationwide population-based study (2010-2017).Eye (London, England) · 2025Article
- Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study.Heliyon · 2025Article
- Blinded by the Mind: Exploring the Hidden Psychiatric Burden in Glaucoma Patients.Biomedicines · 2025Review
- Navigating the intersection of psychiatry and ophthalmology: A comprehensive review of depression and anxiety management in glaucoma patients.World journal of psychiatry · 2024Review
- Relation between a history of glaucoma and subjective happiness: the JPHC-Next study.BMJ open ophthalmology · 2024Article
- Suicide risk in juvenile open angle glaucoma patients.International journal of ophthalmology · 2024Article
- Living alone and the risk of depressive symptoms: a cross-sectional and cohort analysis based on the China Health and Retirement Longitudinal Study.BMC psychiatry · 2023Article
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- Perceived Stress Levels and Associated Factors in Adult Patients with Primary Open-angle Glaucoma: A Prospective Survey Study.Korean journal of ophthalmology : KJO · 2022Article
- Vision-Related Quality of Life and Seasonal Affective Disorder in Patients with Glaucoma and Macular Degeneration.Vision (Basel, Switzerland) · 2022Article
- Mingmu Xiaoyao granules regulate the PI3K/Akt/mTOR signaling pathway to reduce anxiety and depression and reverse retinal abnormalities in rats.Frontiers in pharmacology · 2022Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Risk factors leading to trabeculectomy surgery of glaucoma patient using Japanese nationwide administrative claims data: a retrospective non-interventional cohort study.BMC ophthalmology · 2021Article
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Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious cross-sectional studies revealed a higher prevalence of depression among glaucoma patients. However, cohort studies were in lack to build the risk of incident depression after the diagnosis of glaucoma. The aim of our study was to investigate the association between glaucoma and the subsequent risk of developing depression and to assess risk factors associated with depression in glaucoma patients.
methodsA population-based retrospective cohort study using the Taiwan National Health Insurance Research Database was conducted from January 1, 2001 through December 31, 2011. Glaucoma patients (n = 8777) and age- and gender-matched control subjects without glaucoma (n = 35,108) were enrolled in the study. Kaplan-Meier curves were generated to compare the cumulative hazard of subsequent depression between the glaucoma and control groups. A Cox regression analysis estimated the crude and adjusted hazard ratios (HRs) for depression. Risk factors leading to depression were investigated among the glaucoma patients.
resultsGlaucoma patients had a significantly higher cumulative hazard of depression compared to the control group (p-value < 0.0001). The Cox regression model indicated that the glaucoma group had a significantly higher risk of depression (adjusted HR = 1.71). Within the glaucoma group, significant risk factors for depression included age, female, low income, substance abuse, and living alone. However, the use of β-blocker eye drops and the number of glaucoma medications were not significant risk factors for depression.
conclusionPatients with glaucoma are at significantly greater risk of developing depression. Among glaucoma patients, age, female, low income, substance abuse, and living alone were significant risk factors for depression.
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