Evidence map›Paper›PMID 29929465›Full record

SynthesisCurrent neuropharmacology2019

Suicide Risk in Obsessive-Compulsive Disorder and Exploration of Risk Factors: A Systematic Review.

Umberto Albert, Diana De Ronchi, Giuseppe Maina, Maurizio Pompili

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Current neuropharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. A Systematic Review of Scientific Studies and Case Reports on Music and Obsessive-Compulsive Disorder.International journal of environmental research and public health · 2021
    Pooled it
  2. Determinants of Suicidality in the European General Population: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
    Pooled it
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  10. Psychometric properties of the postpartum thoughts and behaviors checklist.Journal of obsessive-compulsive and related disorders · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Umberto AlbertDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Diana De RonchiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Giuseppe MainaRita Levi Montalcini Department of Neuroscience, University of Torino, Torino, Italy.
Maurizio PompiliDepartment of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
University of Bologna · ITSapienza University of Rome · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHistorically, OCD has been considered to be associated with a relatively low risk of suicide. Recent studies, on the contrary, revealed a significant association between OCD and suicide attempts and ideation. A huge variation in prevalence rates, however, is reported.

objectiveTo estimate prevalence rates of suicide attempts and suicidal ideation in individuals with OCD, and to identify predictors of suicide risk among subjects with OCD.

methodsWe systematically reviewed the literature on suicide risk (ideation and/or attempts) and OCD. We included studies with appropriate definition of OCD, cross-sectional or prospective design, separating clinical samples from epidemiological studies, that employed a quantitative measure of suicidality and/or reported an outcome measure of the association between suicidality and OCD or examined factors associated with suicidality.

resultsIn clinical samples, the mean rate of lifetime suicide attempts is 14.2% (31 studies: range 6- 51.7%). Suicidal ideation is referred by 26.3-73.5% of individuals (17 studies, mean 44.1%); current suicidal ideation rate ranges between 6.4 and 75% (13 studies, mean 25.9). Epidemiological studies found that OCD increases significantly the odds of having a lifetime suicidal ideation as compared to the general population (OR: 1.9-10.3) and a history of lifetime suicide attempts (OR: 1.6- 9.9). Predictors of greater suicide risk are severity of OCD, the symptom dimension of unacceptable thoughts, comorbid Axis I disorders, severity of comorbid depressive and anxiety symptoms, past history of suicidality and some emotion-cognitive factors such as alexithymia and hopelessness.

conclusionOverall, suicidality appears a relevant phenomenon in OCD.

Indexed as

Suicidal IdeationComorbidityCross-Sectional StudiesFemaleHumansMaleObsessive-Compulsive DisorderProspective StudiesRisk FactorsSuicide, Attempteddeaths by suicideObsessive-compulsive disorderpredictorsprevalence ratesrisk factorssuicidal ideationsuicide attempts.

Identifiers

PMID29929465
PMCPMC7059158
OpenAlexW2809302411

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.