Evidence map›Paper›PMID 29929350›Full record

Trial reportThe Korean journal of internal medicine2018

Use of serology and polymerase chain reaction to detect atypical respiratory pathogens during acute exacerbation of chronic obstructive pulmonary disease.

Chi Young Jung, Yeoung Hun Choe, Sang Yeub Lee, Woo Jin Kim, Jong Deog Lee, Seung Won Ra, Eu Gene Choi, Jae Seung Lee, Myung Jae Park, Ju Ock Na

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Korean journal of internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 1 country.

Chi Young JungDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Daegu Catholic University Medical Center, Daegu, Korea.
Yeoung Hun ChoeDivision of Pulmonology and Allergology, Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Korea.
Sang Yeub LeeDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Woo Jin KimDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
Jong Deog LeeDivision of Pulmonology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
Seung Won RaDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea.
Eu Gene ChoiDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Daejeon Hankook Hospital, Daejeon, Korea.
Jae Seung LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Myung Jae ParkDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.
Ju Ock NaDivision of Pulmonology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
Asan Medical Center · KRDaegu Catholic University Medical Center · KRDaejeon Sun Hospital · KRJeonbuk National University Hospital · KRKangwon National University · KRKorea University · KRKyung Hee University Dental Hospital · KRSoonchunhyang University · KRUlsan University Hospital · KRUniversity of Ulsan · KR

Funding

Soonchunhyang University
6 · The paper itself

Abstract

BACKGROUND/

aimsTo use serological and multiplex polymerase chain reaction (PCR) assays to examine sputum samples from patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for the presence of atypical pathogens, including Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila.

methodsFrom September 2012 to February 2014, 341 patients with AECOPD attending outpatient clinics were enrolled as part of a randomized, double-blind, multicenter study. A commercial enzyme-linked immunosorbent assay was used to measure serum immunoglobulin M (IgM) and IgG antibody titers on the first day of the study and at 36 days post-enrollment. Multiplex PCR was used to test sputum samples for the presence of atypical pathogens. A urinary antigen test for L. pneumophila was performed on the first day.

resultsNineteen patients (5.6%) showed serological evidence of acute infection with M. pneumoniae. Also, one and seven patients (2%) showed serological evidence of acute infection with C. pneumoniae and L. pneumophila, respectively. All DNA samples were negative for M. pneumoniae, C. pneumoniae, and L. pneumophila according to PCR. Only one urine sample was positive for L. pneumophila antigen, but serologic evidence was lacking.

conclusionSerological testing suggested that infection by atypical pathogens during AECOPD was relatively uncommon. In addition, PCR provided no direct evidence of infection by atypical pathogens. Thus, atypical pathogens may not be a major cause of AECOPD in South Korea.

Indexed as

Chlamydophila pneumoniaeLegionella pneumophilaMycoplasma pneumoniaePolymerase Chain ReactionPulmonary Disease, Chronic ObstructiveAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedRepublic of KoreaSerologic TestsAtypical pathogenExacerbationPolymerase chain reactionPulmonary disease, chronic obstructiveSerology

Identifiers

PMID29929350
PMCPMC6129643
OpenAlexW2808998353

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.