ArticleThe Science of the total environment2018
Influence of exposure to pesticide mixtures on the metabolomic profile in post-metamorphic green frogs (Lithobates clamitans).
Article in The Science of the total environment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Multifaceted Importance of Amphibians: Ecological, Biomedical, and Socio-Economic Perspectives.Biology · 2026Review
- Co-Exposure with the Herbicide 2,4-D Does Not ExacerbateAnimals : an open access journal from MDPI · 2025Article
- Review
- Validation of Salamander Dermal Mucus Swabs as a Novel, Nonlethal Approach for Amphibian Metabolomics and Glutathione Analysis Following Pesticide Exposure.Environmental toxicology and chemistry · 2024Article
- Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation.Frontiers in ecology and evolution · 2024Article
- 2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers.Toxics · 2024Review
- GC-MS based untargeted metabolomics reveals the metabolic response of earthworm (Eudrilus eugeniae) after chronic combinatorial exposure to three different pesticides.Scientific reports · 2023Article
- Article
- Estimating dermal contact soil exposure for amphibians.Integrated environmental assessment and management · 2023Article
- Differentiating metabolomic responses of amphibians to multiple stressors.The Science of the total environment · 2022Article
- Using metabolomic profiling to inform use of surrogate species in ecological risk assessment practices.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2022Article
- Induced Hepatic Glutathione and Metabolomic Alterations Following Mixed Pesticide and Fertilizer Exposures in Juvenile Leopard Frogs (Lithobates sphenocephala).Environmental toxicology and chemistry · 2022Article
- Examination of Physiological and Morphological Differences between Farm-Bred and Wild Black-Spotted Pond Frogs (Life (Basel, Switzerland) · 2021Article
- Route of exposure influences pesticide body burden and the hepatic metabolome in post-metamorphic leopard frogs.The Science of the total environment · 2021Article
- Toxicity of fipronil and 2,4-D formulations (alone and in a mixture) to the tropical amphipod Hyalella meinerti.Environmental science and pollution research international · 2021Article
- Hybrid Process of Adsorption/Coagulation/Ceramic MF for Removing Pesticides in Drinking Water Treatment-Inline vs. Contact Tank PAC Dosing.Membranes · 2021Article
- Ecological and toxicological assessments of anthropogenic contaminants based on environmental metabolomics.Environmental science and ecotechnology · 2021Review
- Use of Integrative Interactomics for Improvement of Farm Animal Health and Welfare: An Example with Fescue Toxicosis.Toxins · 2020Review
- Avoidance behavior of juvenile common toads (Bufo bufo) in response to surface contamination by different pesticides.PloS one · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Pesticide use in agricultural areas requires the application of numerous chemicals to control target organisms, leaving non-target organisms at risk. The present study evaluates the hepatic metabolomic profile of one group of non-target organisms, amphibians, after exposure to a single pesticide and pesticide mixtures. Five common-use pesticide active ingredients were used in this study, three herbicides (atrazine, metolachlor and 2,4-d), one insecticide (malathion) and one fungicide (propiconazole). Juvenile green frogs (Lithobates clamitans) were reared for 60-90days post-metamorphosis then exposed to a single pesticide or a combination of pesticides at the labeled application rate on soil. Amphibian livers were excised for metabolomic analysis and pesticides were quantified for whole body homogenates. Based on the current study, metabolomic profiling of livers support both individual and interactive effects where pesticide exposures altered biochemical processes, potentially indicating a different response between active ingredients in pesticide mixtures, among these non-target species. Amphibian metabolomic response is likely dependent on the pesticides present in each mixture and their ability to perturb biochemical networks, thereby confounding efforts with risk assessment.
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Registered trials
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