Evidence map›Paper›PMID 29928998›Full record

ArticleClinical immunology (Orlando, Fla.)2018

Interleukin-1 in monocyte activation phenotypes in systemic juvenile idiopathic arthritis: Observations from a clinical trial of rilonacept, an interleukin-1 inhibitor.

Yujuan Zhang, Saloni Gupta, Alexandra Ilstad-Minnihan, Sashi Ayyangar, Arielle D Hay, Virginia Pascual, Norman T Ilowite, Claudia Macaubas, Elizabeth D Mellins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yujuan ZhangDepartment of Pediatrics, Program in Immunology, Stanford University, Stanford, CA, USA.
Saloni GuptaDepartment of Pediatrics, Program in Immunology, Stanford University, Stanford, CA, USA.
Alexandra Ilstad-MinnihanDepartment of Pediatrics, Program in Immunology, Stanford University, Stanford, CA, USA.
Sashi AyyangarDepartment of Pediatrics, Program in Immunology, Stanford University, Stanford, CA, USA.
Arielle D HayChildren's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA.
Virginia PascualBaylor Institute for Immunology Research, Dallas, TX, USA.
Norman T IlowiteChildren's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA.
Claudia MacaubasDepartment of Pediatrics, Program in Immunology, Stanford University, Stanford, CA, USA. Electronic address: macaubas@stanford.edu.
Elizabeth D MellinsDepartment of Pediatrics, Program in Immunology, Stanford University, Stanford, CA, USA. Electronic address: mellins@stanford.edu.
Stanford University · USChildren's Hospital at Montefiore · USBaylor University · US

Funding

Training Program in Adult and Pediatric RheumatologyT32AR050942 · NIAMS · STANFORD UNIVERSITY · PI LEWIS, DAVID BRAM, ROBINSON, WILLIAM H · 2005 to 2025
$6.6M
A role for IL-1 in SJIA monocyte phenotypes: A RAPPORT ancillary studyR01AR061297 · NIAMS · STANFORD UNIVERSITY · PI MELLINS, ELIZABETH D · 2010 to 2013
$1.2M
Immune cell dysfunction in SJIAR21AI075254 · NIAID · STANFORD UNIVERSITY · PI MELLINS, ELIZABETH D · 2008 to 2009
$435k
Inflammasome function and SJIAR21AR062765 · NIAMS · STANFORD UNIVERSITY · PI MELLINS, ELIZABETH D · 2012 to 2013
$382k
NIAID NIH HHS R21 AI075254NIAMS NIH HHS R01 AR061297NIAMS NIH HHS R21 AR062765NIAMS NIH HHS T32 AR050942
6 · The paper itself

Abstract

Systemic juvenile idiopathic arthritis (sJIA) is a childhood rheumatic disease of unknown origin. Dysregulated innate immunity is implicated in disease pathology. We investigated if IL-1 inhibition affects circulating cytokines and monocyte gene expression. CD14+ monocytes from patients in the RAPPORT trial were analyzed by RT-PCR for expression of IL1B and transcription factors associated with monocyte activation. Serum IL-1ra decreased with treatment, and IL-18BP transiently increased. Serum levels of IL-1β, IL-6, IL-10 and IL-18 were unchanged. IRF5 and STAT6 were decreased, and PPARG was increased, independent of clinical response, and may represent a skew toward a PPARG-driven M2-like phenotype. IL1B expression was decreased in early clinical responders. A transient increase in STAT1, and a decrease in SOCS1 preceded the reduction in IL1B in early clinical responders. Changes in IL1B/STAT1/SOCS1 could be associated with crosstalk between IL-1 and IFN pathways in sJIA. These transcriptional changes might be useful as drug response biomarkers.

Indexed as

Arthritis, JuvenileClinical Trials as TopicHumansImmunity, InnateInterleukin-1Interleukin-1betaMonocytesRandomized Controlled Trials as TopicRecombinant Fusion ProteinsSignal TransductionSTAT1 Transcription FactorSuppressor of Cytokine Signaling 1 ProteinInterleukin-1Interleukin-1betaRecombinant Fusion ProteinsrilonaceptSTAT1 Transcription FactorSuppressor of Cytokine Signaling 1 ProteinJuvenile arthritisMonocytes;cytokine

Identifiers

PMID29928998
PMCPMC6089654
OpenAlexW2808718827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.