ReviewAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2018
Heterogeneity and the origins of asthma.
Review in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Longitudinal dynamics and site-specific recovery of the human respiratory microbiome following smoking cessation.Respiratory research · 2026Article
- Differences in microRNA levels across metabo-endotypes reveal novel insights into asthma heterogeneity.Respiratory research · 2026Article
- Asthma Phenotype Progression in Children and Adolescents: A Single Center Experience.Pediatric pulmonology · 2025Article
- The Associations of Anaemia Status and Body Mass Index with Asthma Severity in Saudi Arabia: A Comparative Study.Journal of asthma and allergy · 2025Article
- Gut microbiota dysbiosis and its impact on asthma and other lung diseases: potential therapeutic approaches.The Korean journal of internal medicine · 2024Review
- Review
- Ιnterleukin-17A-Enriched Neutrophil Extracellular Traps Promote Immunofibrotic Aspects of Childhood Asthma Exacerbation.Biomedicines · 2023Article
- Association between tobacco product use and asthma among US adults from the Population Assessment of Tobacco and Health (PATH) Study waves 2-4.BMJ open respiratory research · 2023Article
- Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma.Nutrients · 2023Review
- How does cigarette smoking affect airway remodeling in asthmatics?Tobacco induced diseases · 2023Review
- Skin Barrier Function and Infant Tidal Flow-Volume Loops-A Population-Based Observational Study.Children (Basel, Switzerland) · 2022Article
- Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study.ERJ open research · 2022Article
- Article
- Association between the prevalence of obstructive lung disease and the use of aspirin in a diabetic population.Interventional pulmonology (Middletown, Del.) · 2022Article
- Identification of Key Signaling Pathways and Genes in Eosinophilic Asthma and Neutrophilic Asthma by Weighted Gene Co-Expression Network Analysis.Frontiers in molecular biosciences · 2022Article
- "Liquid biopsy" - extracellular vesicles as potential novel players towards precision medicine in asthma.Frontiers in immunology · 2022Review
- Packaging and Delivery of Asthma Therapeutics.Pharmaceutics · 2021Review
- A review on the effect of COVID-19 in type 2 asthma and its management.International immunopharmacology · 2021Review
- Investigating the Outcomes of an Asthma Educational Program and Useful Influence in Public Policy.Frontiers in public health · 2021Article
- Single Nucleotide and Copy-Number Variants in IL4 and IL13 Are Not Associated with Asthma Susceptibility or Inflammatory Markers: A Case-Control Study in a Mexican-Mestizo Population.Diagnostics (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the roots of asthma across different ages, including atopy, the role of the microbiome and viral infections, and comorbidities and confounders, such as obesity, aspirin-exacerbated respiratory disease, neutrophilic asthma, cigarette smoking, and the possibility of an asthma-chronic obstructive pulmonary disease overlap syndrome. DATA SOURCES: Data were taken from various scientific search engines, including PubMed and Science Direct databases. STUDY SELECTIONS: Articles that reviewed information on the origins of asthma in persons of all ages, including different phenotypes and genotypes of asthma, were used.
resultsAsthma is a common and complex disease whose origins are likely a combination of both genetic predisposition and environmental exposures. Factors such as the microbiome, other atopic disease, viral infections in young children, and other diagnoses, such as obesity or aspirin-exacerbated respiratory disease, are important to consider when creating a treatment plan for patients.
conclusionAsthma is a disease that is often diagnosed in childhood but can present at any age. There is debate in the field as to whether asthma is one disease or several different diseases that include airway inflammation as a key finding. There are risk factors for disease in the environment and through comorbidities that likely play significant roles in the origins of asthma, the development of symptoms, and the response to treatment. These factors are even more important as we look toward the future with the goal of personalized medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.