ArticleNMR in biomedicine2018
Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells.
Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Molecular Imaging: Unveiling Metabolic Abnormalities in Pancreatic Cancer.International journal of molecular sciences · 2025Review
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- Metabolomic Analysis of Histological Composition Variability of High-Grade Serous Ovarian Cancer UsingInternational journal of molecular sciences · 2024Article
- Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake.Clinical and translational medicine · 2024Article
- Cytotoxic Effect ofCurrent issues in molecular biology · 2024Article
- Biophysical Insights into the Antitumoral Activity of Crotalicidin against Breast Cancer Model Membranes.International journal of molecular sciences · 2023Article
- GPD1 inhibits the carcinogenesis of breast cancer through increasing PI3K/AKT-mediated lipid metabolism signaling pathway.Heliyon · 2023Article
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- Metabolomic analysis of endometrial cancer by high-resolution magic angle spinning NMR spectroscopy.Archives of gynecology and obstetrics · 2022Article
- LC-MS Based Lipidomics Depict Phosphatidylethanolamine as Biomarkers of TNBC MDA-MB-231 over nTNBC MCF-7 Cells.International journal of molecular sciences · 2022Article
- Review
- The ETNK2 gene promotes progression of papillary thyroid carcinoma through the HIPPO pathway.Journal of Cancer · 2022Article
- Grading of endometrial cancer usingScientific reports · 2021Article
- Differences in lipidomics may be potential biomarkers for early diagnosis of pancreatic cancer.Acta cirurgica brasileira · 2020Article
- Contradiction between amide-CEST signal and pH in breast cancer explained with metabolic MRI.NMR in biomedicine · 2019Article
- Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Elevated phosphoethanolamine (PE) is frequently observed in MRS studies of human cancers and xenografts. The role of PE in cell survival and the molecular causes underlying this increase are, however, relatively underexplored. In this study, we investigated the roles of ethanolamine kinases (Etnk-1 and 2) and choline kinases (Chk-α and β) in contributing to increased PE in human breast and pancreatic cancer cells. We investigated the effect of silencing Etnk-1 and Etnk-2 on cell viability as a potential therapeutic strategy. Both breast and pancreatic cancer cells showed higher PE compared with their nonmalignant counterparts. We identified Etnk-1 as a major cause of the elevated PE levels in these cancer cells, with little or no contribution from Chk-α, Chk-β, or Etnk-2. The increase of PE observed in pancreatic cancer cells in culture was replicated in the corresponding tumor xenografts. Downregulation of Etnk-1 with siRNA resulted in cell cytotoxicity that correlated with PE levels in breast and pancreatic cancer cells. Etnk-1 may provide a potential therapeutic target in breast and pancreatic cancers.
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