Evidence map›Paper›PMID 29928763›Full record

ReviewThe Journal of physiology2018

Antenatal prevention of cerebral palsy and childhood disability: is the impossible possible?

Stacey J Ellery, Meredith Kelleher, Peta Grigsby, Irina Burd, Jan B Derks, Jon Hirst, Suzanne L Miller, Larry S Sherman, Mary Tolcos, David W Walker

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Stacey J ElleryThe Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.
Meredith KelleherOregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
Peta GrigsbyOregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
Irina BurdDepartment of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD, USA.
Jan B DerksDepartment of Perinatal Medicine University Medical Center Utrecht, The Netherlands, Gynaecology, Monash University, Melbourne, Australia.
Jon HirstUniversity of Newcastle, Newcastle, Australia.
Suzanne L MillerThe Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.ORCID 0000-0002-0451-8304
Larry S ShermanOregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA.
Mary TolcosSchool of Health & Biomedical Sciences, RMIT University, Bundoora, Melbourne, Australia.
David W WalkerThe Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.ORCID 0000-0002-4958-6140
Hudson Institute of Medical Research · AUOregon National Primate Research Center · USJohns Hopkins University · USMonash Medical Centre · AURMIT University · AUUniversity of Newcastle Australia · AU

Funding

Primate model of mid-gestation Ureaplasma in utero infection: Prevention of neuroR01HD069610 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI GRIGSBY, PETA LOUISE · 2012 to 2016
$2.9M
The Role of Choriodecidual Infection in the Pathogenesis of Preterm Birth and Inflammatory Brain InjuryK99HD090229 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLEHER, MEREDITH ANNE · 2017 to 2018
$184k
Cerebral Palsy Alliance PG8816Department of Health, Australian Government, National Health and Medical Research Council GNT1003517Department of Health, Australian Government, National Health and Medical Research Council GNT1124493Financial Markets Foundation for ChildrenNICHD NIH HHS K99 HD090229NICHD NIH HHS R01 HD069610
6 · The paper itself

Abstract

This review covers our current knowledge of the causes of perinatal brain injury leading to cerebral palsy-like outcomes, and argues that much of this brain damage is preventable. We review the experimental evidence that there are treatments that can be safely administered to women in late pregnancy that decrease the likelihood and extent of perinatal brain damage that occurs because of acute and severe hypoxia that arises during some births, and the additional impact of chronic fetal hypoxia, infection, inflammation, growth restriction and preterm birth. We discuss the types of interventions required to ameliorate or even prevent apoptotic and necrotic cell death, and the vulnerability of all the major cell types in the brain (neurons, astrocytes, oligodendrocytes, microglia, cerebral vasculature) to hypoxia/ischaemia, and whether a pan-protective treatment given to the mother before birth is a realistic prospect.

Indexed as

AnimalsCerebral PalsyChildChildren with DisabilitiesFetal DevelopmentFetal HypoxiaHumansInfectionsInflammationPremature Birthcerebral palsyneuroprotectionOxidative stressperinatal brain damageprophylaxis

Identifiers

PMID29928763
PMCPMC6265564
OpenAlexW2891345925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.