ArticleInfectious Disease Modelling2017
Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in
Article in Infectious Disease Modelling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health, Economic, and Social Impacts of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review of Methodological Approaches.The American journal of tropical medicine and hygiene · 2023Pooled it
- Modeling the Impact of Malaria Chemoprevention with sulphadoxine-pyrimethamine on the spread ofInfectious Disease Modelling · 2026Article
- Wonder drugs and where to use them: a forecast of ivermectin's impact on malaria in Africa.Infectious Disease Modelling · 2025Article
- Dynamics and Persistence of a Generalized Multi-strain SIS Model.Bulletin of mathematical biology · 2025Article
- Modeling the Health and Economic Impact of Substandard and Falsified Medicines: A Review of Existing Models and Approaches.The American journal of tropical medicine and hygiene · 2022Review
- Immune selection suppresses the emergence of drug resistance in malaria parasites but facilitates its spread.PLoS computational biology · 2021Article
- Brief Report: Antimalarial Benefit of HIV Antiretroviral Therapy in Areas of Low to Moderate Malaria Transmission Intensity.Journal of acquired immune deficiency syndromes (1999) · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of poor quality antimalarial medicines, including the use of non-recommended medicines for treatment such as sulfadoxine-pyrimethamine (SP) monotherapy, undermines malaria control and elimination efforts. Furthermore, the use of subtherapeutic doses of the active ingredient(s) can theoretically promote the emergence and transmission of drug resistant parasites.
methodsWe developed a deterministic compartmental model to quantify the impact of antimalarial medicine quality on the transmission of SP resistance, and validated it using sensitivity analysis and a comparison with data from Kenya collected in 2006. We modelled human and mosquito population dynamics, incorporating two
findingsThe model predicted that an increase in human malaria cases, and among these, an increase in the proportion of SP-resistant infections, resulted from an increase in poor quality SP antimalarial use, whether it was full- or half-dose SP monotherapy.
interpretationOur findings suggest that an increase in poor quality antimalarial use predicts an increase in the transmission of resistance. This highlights the need for stricter control and regulation on the availability and use of poor quality antimalarial medicines, in order to offer safe and effective treatments, and work towards the eradication of malaria.
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Registered trials
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