ArticleInfectious Disease Modelling2017
Modelling the HIV persistence through the network of lymphocyte recirculation in vivo.
Article in Infectious Disease Modelling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Optimal therapy for HIV infection containment and virions inhibition.Infectious Disease Modelling · 2024Article
- Modeling HIV-1 infection in the brain.PLoS computational biology · 2020Article
- Comparison of different strategies for controlling HIV/AIDS spreading in MSM.Infectious Disease Modelling · 2018Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
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Abstract
Human Immunodeficiency Virus (HIV) is able to persist in cellular and/or anatomical viral reservoirs, despite the effective inhibition of virus replication by the antiretroviral therapy (ART). Here we develop a mathematical model to gain some insights of HIV persistence relevant to the lymphocyte recirculation network of immune system and the central nervous system (CNS). Our simulations and analyses illustrate the role of the CNS as a virus reservoir to prevent antiretroviral drugs from penetrating the blood-brain (or blood-testis) barrier, and we examine the long-term impact of this reservoir on the transmissibility of an infected individual. We observe numerically that level of HIV in peripheral blood may not accurately reflect the true mechanisms occurring within other organs.
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