ArticleCellular and molecular gastroenterology and hepatology2018
Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations.
Article in Cellular and molecular gastroenterology and hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Dual states of murine Bmi1-expressing intestinal stem cells drive epithelial development utilizing non-canonical Wnt signaling.Developmental cell · 2025Article
- A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration.Development (Cambridge, England) · 2025Article
- Development of rat duodenal monolayer model with effective barrier function from rat organoids for ADME assay.Scientific reports · 2023Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Article
- A technology of a different sort: microraft arrays.Lab on a chip · 2021Review
- Article
- Signaling Network Centered on mTORC1 Dominates Mammalian Intestinal Stem Cell Ageing.Stem cell reviews and reports · 2021Review
- P16Frontiers in cell and developmental biology · 2021Article
- Stem Cell Marker Expression in Early Stage Colorectal Cancer is Associated with Recurrent Intestinal Neoplasia.World journal of surgery · 2020Article
- Lgr5 and stem/progenitor gene expression in gastric/gastroesophageal junction carcinoma - significance of potentially retained stemness.BMC cancer · 2020Article
- Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach.Nature communications · 2019Article
- Effect of Antifreeze Glycoproteins on Organoid Survival during and after Hypothermic Storage.Biomolecules · 2019Article
- Decrypting the Crypt: Novel Monoclonal Antibodies to Identify Intestinal Stem Cell Populations.Cellular and molecular gastroenterology and hepatology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsContinual renewal of the intestinal epithelium is dependent on active- and slow-cycling stem cells that are confined to the crypt base. Tight regulation of these stem cell populations maintains homeostasis by balancing proliferation and differentiation to support critical intestinal functions. The hierarchical relation of discrete stem cell populations in homeostasis or during regenerative epithelial repair remains controversial. Although recent studies have supported a model for the active-cycling leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)
methodsWe used novel monoclonal antibodies (mAbs) raised against murine intestinal epithelial cells in conjunction with ISC-green fluorescent protein (GFP) reporter mice to analyze relations between ISC populations by microscopy. Ex vivo 3-dimensional cultures, flow cytometry, and quantitative reverse-transcription polymerase chain reaction analyses were performed.
resultsTwo novel mAbs recognized distinct subpopulations of the intestinal epithelium and when used in combination permitted isolation of discrete Lgr5
conclusionsThese data showed the functional utility of murine mAbs in the isolation and investigation of Lgr5
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.