ArticleAnnals of clinical and translational neurology2018
Cortical alterations in phobic postural vertigo - a multimodal imaging approach.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Neuroimaging studies in persistent postural-perceptual dizziness and related disease: a systematic review.Journal of neurology · 2022Pooled it
- Brain activation in persistent postural-perceptual dizziness (PPPD) in response to various visual motion stimuli eliciting abnormal egomotion perception.NeuroImage. Clinical · 2026Article
- Attentional dysfunction in persistent postural-perceptual dizziness: a narrative review of mechanistic evidence.Frontiers in neurology · 2026Review
- Spatial Orientation Impairment in Patients With Bilateral Vestibulopathy and Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Article
- Functional brain activity in persistent postural-perceptual dizziness (PPPD) during galvanic vestibular stimulation reveals sensitization in the multisensory vestibular cortical network.Scientific reports · 2025Article
- Diagnostics and Group Therapy in Patients with Persistent Postural-Perceptual Dizziness and Anxiety Disorder: Biomarkers and Neurofunctional Correlates of Underlying Treatment Effects.Diagnostics (Basel, Switzerland) · 2025Article
- Efficacy and Safety Analysis of Repetitive Transcranial Magnetic Stimulation in Patients with Persistent Postural Perceptual Dizziness: A Single-Center, Single-Blind, Randomized Placebo-Controlled Trial.Neurology and therapy · 2025Article
- Research Progress on the Potential Pathogenesis of Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Review
- Visual and vestibular motion perception in persistent postural-perceptual dizziness (PPPD).Journal of neurology · 2024Article
- Changes in functional connectivity among vestibulo-visuo-somatosensory and spatial cognitive cortical areas in persistent postural-perceptual dizziness: resting-state fMRI studies before and after visual stimulation.Frontiers in neurology · 2023Article
- Altered Neuromagnetic Activity in Persistent Postural-Perceptual Dizziness: A Multifrequency Magnetoencephalography Study.Frontiers in human neuroscience · 2022Article
- Reduced vestibular perception thresholds in persistent postural-perceptual dizziness- a cross-sectional study.BMC neurology · 2021Article
- Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies.Journal of clinical medicine · 2021Review
- Network changes in patients with phobic postural vertigo.Brain and behavior · 2020Article
- Neural Correlates of Transient Mal de Debarquement Syndrome: Activation of Prefrontal and Deactivation of Cerebellar Networks Correlate With Neuropsychological Assessment.Frontiers in neurology · 2020Article
- DIZZYNET 2019: approaching the future of vestibular research.Journal of neurology · 2019Article
- Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFunctional dizziness syndromes are among the most common diagnoses made in patients with chronic dizziness, but their underlying neural characteristics are largely unknown. The aim of this neuroimaging study was to analyze the disease-specific brain changes in patients with phobic postural vertigo (PPV).
methodsWe measured brain morphology, task response, and functional connectivity in 44 patients with PPV and 44 healthy controls.
resultsThe analyses revealed a relative structural increase in regions of the prefrontal cortex and the associated thalamic projection zones as well as in the primary motor cortex. Morphological increases in the ventrolateral prefrontal cortex positively correlated with disease duration, whereas increases in dorsolateral, medial, and ventromedial prefrontal areas positively correlated with the Beck depression index. Visual motion stimulation caused an increased task-dependent activity in the subgenual anterior cingulum and a significantly longer duration of the motion aftereffect in the patients. Task-based functional connectivity analyses revealed aberrant involvement of interoceptive, fear generalization, and orbitofrontal networks.
interpretationOur findings agree with some of the typical characteristics of functional dizziness syndromes, for example, excessive self-awareness, anxious appraisal, and obsessive controlling of posture. This first evidence indicates that the disease-specific mechanisms underlying PPV are related to networks involved in mood regulation, fear generalization, interoception, and cognitive control. They do not seem to be the result of aberrant processing in cortical visual, visual motion, or vestibular regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.