Evidence map›Paper›PMID 29928592›Full record

ArticleToxicology reports2018

Complex toxicity as disruption of adipocyte or osteoblast differentiation in human mesenchymal stem cells under the mixed condition of TBBPA and TCDD.

Hideki Kakutani, Tomohiro Yuzuriha, Ema Akiyama, Teruyuki Nakao, Souichi Ohta

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. 2,4-D causes oxidative stress induction and apoptosis in human dental pulp stem cells (hDPSCs).Environmental science and pollution research international · 2019
    Article
  6. Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2019
    Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hideki KakutaniLaboratory of Disease Prevention, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Tomohiro YuzurihaLaboratory of Disease Prevention, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Ema AkiyamaLaboratory of Disease Prevention, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Teruyuki NakaoLaboratory of Disease Prevention, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Souichi OhtaLaboratory of Disease Prevention, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Setsunan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People are frequently and unintentionally exposed to many chemical compounds, such as environmental pollutants and endocrine-disrupting chemicals (EDCs), in food and from the atmosphere. In particular, endocrine-disrupting TBBPA and dioxins are found in human breast milk and in the body. Conventional studies evaluate toxicity by administering a single substance to cells or animals, but evaluation of the toxicity of mixtures of these ingested compounds is essential for "true" toxicological assessment. We evaluated toxic effects

Indexed as

2,3,7,8-tetrachlorodibenzo-p-dioxinAdipocyte differentiationALP, alkaline phosphataseaP2, adipocyte-specific protein 2BFRs, brominated flame retardantsC/EBPα, CCAAT-enhancer-binding protein alphaDOHaD, developmental origins of health and diseaseEDCs, endocrine-disrupting chemicalsHuman mesenchymal stem cellLPL, lipoprotein lipaseMSC, mesenchymal stem cellOsteoblast differentiationPCDDs/DFs, polychlorinated dibenzo-p-dioxins and dibenzofuransPPARγ, peroxisome proliferator activated receptor gammaRUNX2, runt-related transcription factor 2TBBPA, tetrabromobisphenol ATCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinTetrabromobisphenol A

Identifiers

PMID29928592
PMCPMC6008500
OpenAlexW2807938753

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.