ArticleFEBS open bio2018
Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l-threonine aldolase from
Article in FEBS open bio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Electrostatic tuning of the pyridoxal-5'-phosphate cofactor site defines pH dependence in type I cystathionine β-lyases.The Journal of biological chemistry · 2026Article
- Enhancing Diastereoselectivity of l‑Threonine Aldolase by Strengthening Kinetic Control To Mitigate Thermodynamic Equilibrium.Chem & bio engineering · 2026Article
- Mutation of active site glutamate in serine hydroxymethyltransferase allows trapping a reactive intermediate: a combined neutron and X-ray crystallography study.RSC advances · 2026Article
- Profiling of Diverse Pyridoxal-5'-Phosphate Dependent Enzymes Reveals Promiscuous Aldolase Activity with (2-Azaaryl)methanamines.Journal of the American Chemical Society · 2025Article
- Molecular Basis for Cγ-N Bond Formation by PLP-Dependent Enzyme LolC.Biochemistry · 2024Article
- A recombinant L-threonine aldolase with high catalytic efficiency for the asymmetric synthesis of L-threo-phenylserine and L-threo-4-fluorophenylserine.Biotechnology letters · 2024Article
- Edodin: A New Type of Toxin from Shiitake Mushroom (Toxins · 2024Article
- Molecular Insights into the Enhanced Activity and/or Thermostability of PET Hydrolase by D186 Mutations.Molecules (Basel, Switzerland) · 2024Article
- Comprehensive screening strategy coupled with structure-guided engineering of l-threonine aldolase fromFrontiers in bioengineering and biotechnology · 2023Article
- Isolation and characterization of mimosine degrading enzyme from Arthrobacter sp. Ryudai-S1.World journal of microbiology & biotechnology · 2022Article
- Second-Shell Amino Acid R266 Helps DetermineBiochemistry · 2021Article
- Inhibitors of bacterial HScience (New York, N.Y.) · 2021Article
- Bioinformatic analysis of subfamily-specific regions in 3D-structures of homologs to study functional diversity and conformational plasticity in protein superfamilies.Computational and structural biotechnology journal · 2021Article
- Zebra2: advanced and easy-to-use web-server for bioinformatic analysis of subfamily-specific and conserved positions in diverse protein superfamilies.Nucleic acids research · 2020Article
- Distant Non-Obvious Mutations Influence the Activity of a HyperthermophilicBiomolecules · 2019Article
- The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.Nucleic acids research · 2019Article
- Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions.Frontiers in bioengineering and biotechnology · 2019Article
- Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.Frontiers in molecular biosciences · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of improved variants of enzymes/proteins, but represents a methodological challenge. The pyridoxal-5'-phosphate (PLP)-dependent enzymes are catalytically diverse and include the aspartate aminotransferase superfamily which implements a common structural framework known as type fold I. In this work, the recently developed bioinformatic online methods Mustguseal and Zebra were used to collect and study a large representative set of the aspartate aminotransferase superfamily with high structural, but low sequence similarity to l-threonine aldolase from
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.