ArticleNPJ aging and mechanisms of disease2018
A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type
Article in NPJ aging and mechanisms of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
43 citing papers in PubMed, 67 citations in OpenAlex.
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- A non-canonical role of somatic Cyclin D/CYD-1 in oogenesis and in maintenance of reproductive fidelity, dependent on the FOXO/DAF-16 activation state.PLoS genetics · 2024Article
- Biological constraint, evolutionary spandrels and antagonistic pleiotropy.Ageing research reviews · 2024Review
- Characterization of Effects of mTOR Inhibitors on Aging in Caenorhabditis elegans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
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- Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?Aging · 2023Article
- C. elegans ageing is accelerated by a self-destructive reproductive programme.Nature communications · 2023Article
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- Multigenerational downregulation of insulin/IGF-1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing.Evolution; international journal of organic evolution · 2022Article
- Fusion and expansion of vitellogenin vesicles during Caenorhabditis elegans intestinal senescence.Aging cell · 2022Article
- Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice.Aging · 2022Article
- Hallmarks of cancer and hallmarks of aging.Aging · 2022Article
- As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan.Aging · 2022Article
- A tandem segmentation-classification approach for the localization of morphological predictors ofAging · 2022Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
A long-standing belief is that aging (senescence) is the result of stochastic damage accumulation. Alternatively, senescent pathology may also result from late-life, wild-type gene action (i.e., antagonistic pleiotropy, as argued by Williams) leading to non-adaptive run-on of developmental programs (or
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.